{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:14:03Z","timestamp":1790741643359,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T00:00:00Z","timestamp":1450915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Psychogenic nonepileptic seizures (<jats:styled-content style=\"fixed-case\">PNES<\/jats:styled-content>) often have a debilitating effect on patients\u2019 lives. Patients, family members, and clinicians have yet to fully understand the mechanisms and treatment of this disorder. Although reviews exist about epileptic seizures, there have been no systematic reviews of studies focusing on the impact of<jats:styled-content style=\"fixed-case\">PNES<\/jats:styled-content>. This review considers research on factors associated with the health\u2010related quality of life (<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL) of patients with<jats:styled-content style=\"fixed-case\">PNES<\/jats:styled-content>. Searches of Medline, PsycINFO,<jats:styled-content style=\"fixed-case\">CINAHL<\/jats:styled-content>, and Cochrane Library were conducted. Search terms identified studies that examined factors associated with<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in<jats:styled-content style=\"fixed-case\">PNES<\/jats:styled-content>. Factors fell into three categories: (1) seizure and somatic factors, (2) psychological factors, and (3) coping strategies and family functioning. Fourteen articles were included. The majority of studies were cross\u2010sectional and were of weak to moderate quality. Depressive symptoms were negatively associated with<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL. Other factors associated with poorer<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL included dissociation, somatic symptoms, escape\u2010avoidance coping strategies, and family dysfunction. Variables such as seizure frequency and demographic factors were not significantly associated with<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL. Psychological and interpersonal factors, not seizure reduction, are important for the<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL of patients with<jats:styled-content style=\"fixed-case\">PNES<\/jats:styled-content>. The avoidance of emotions is proposed as a perpetuating factor in the difficulties associated with poorer<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL. A\u00a0biopsychosocial approach has relevance for both the clinical and theoretical understanding of<jats:styled-content style=\"fixed-case\">PNES<\/jats:styled-content>. Larger scale research on psychological and relational factors is needed to inform therapeutic approaches to enhance<jats:styled-content style=\"fixed-case\">HRQ<\/jats:styled-content>oL in patients with<jats:styled-content style=\"fixed-case\">PNES<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/epi.13268","type":"journal-article","created":{"date-parts":[[2015,12,24]],"date-time":"2015-12-24T05:24:54Z","timestamp":1450934694000},"page":"171-181","source":"Crossref","is-referenced-by-count":114,"title":["Correlates of health\u2010related quality of life in adults with psychogenic nonepileptic seizures: A systematic review"],"prefix":"10.1111","volume":"57","author":[{"given":"Becky","family":"Jones","sequence":"first","affiliation":[{"name":"Department of Psychology University of Sheffield Sheffield United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Reuber","sequence":"additional","affiliation":[{"name":"Sheffield Teaching Hospitals NHS 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