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Six gray literature databases (e.g., American Academy of Neurology [AAN], ILAE) were also searched to minimize publication bias. Two independent reviewers screened abstracts, reviewed full text articles, and performed data abstraction. Descriptive statistics and a meta\u2010analysis were generated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The search identified 10,926 abstracts. Of the 410 articles selected for full text review, 63 met our eligibility criteria for a guideline. Of those included, 54 were in English and 9 were in other languages (French, Spanish, and Italian). Of all guidelines, 29% did not specify the target age groups, 27% were focused on adults, 22% included only children, and 6% specifically addressed issues related to women with epilepsy. Guidelines included in the review were most often aimed at guiding clinical practice for status epilepticus (n = 7), first seizure (n = 6), drug\u2010resistant epilepsy (n = 5), and febrile seizures (n = 4), among others. Most of the guidelines were therapeutic (n = 35) or diagnostic (n = 16) in nature. The quality of the guidelines using a 1\u20137 point scale (7 = highest) varied and was moderate overall (mean = 4.99 \u00b1 1.05 [SD]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We identified substantial gaps in topics (e.g., epilepsy in the elderly) and there was considerable heterogeneity in methodologic quality. The findings should offer a valuable resource for health professionals caring for people with epilepsy, since they will help guide the prioritization, development, and dissemination of future epilepsy\u2010related guidelines.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13273","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T04:45:01Z","timestamp":1449981901000},"page":"13-23","source":"Crossref","is-referenced-by-count":61,"title":["The current state of epilepsy guidelines: A systematic review"],"prefix":"10.1111","volume":"57","author":[{"given":"Khara M.","family":"Sauro","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences and Hotchkiss Brain Institute Cumming School of Medicine University of Calgary Calgary Alberta Canada"},{"name":"Department of Community Health Sciences and O'Brien Institute for Public Health Cumming School of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Wiebe","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurosciences and Hotchkiss Brain Institute Cumming School of Medicine University of Calgary Calgary Alberta Canada"},{"name":"Department of Community Health Sciences and O'Brien Institute for Public Health Cumming School of Medicine University of Calgary Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Dunkley","sequence":"additional","affiliation":[{"name":"Department of Paediatrics Kings Mill Hospital Sutton in Ashfield United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozsef","family":"Janszky","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Pecs Pecs Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kumlien","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Neurology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solomon","family":"Mosh\u00e9","sequence":"additional","affiliation":[{"name":"Saul R. Korey Department of Neurology Dominick P. Purpura Department of Neuroscience and Department of Pediatrics Laboratory of Developmental Epilepsy Montefiore\/Einstein Epilepsy Management Center Albert Einstein College of Medicine and Montefiore Medical Center Bronx New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobukazu","family":"Nakasato","sequence":"additional","affiliation":[{"name":"Department of Epileptology Tohoku University School of Medicine Tohoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy A.","family":"Pedley","sequence":"additional","affiliation":[{"name":"Department of Neurology Neurological Institute of New York Columbia University Medical Center New York New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Perucca","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine &amp; Therapeutics Unit of Clinical and Experimental Pharmacology University of Pavia and C. 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