{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:12:32Z","timestamp":1781082752740,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,12]],"date-time":"2015-12-12T00:00:00Z","timestamp":1449878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The University of Michigan Department of Pediatrics and Communicable Diseases"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>We aimed to determine the diagnostic yield of continuous monitoring with video electroencephalography (<jats:styled-content style=\"fixed-case\">cVEEG<\/jats:styled-content>) for pediatric inpatients with paroxysmal vital sign changes (<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s), and to identify risk factors for the<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s being seizures, based on clinical information available before<jats:styled-content style=\"fixed-case\">cVEEG<\/jats:styled-content>initiation. We hypothesized that<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s without nonautonomic symptoms (<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>) were unlikely to be seizures, and also that patients' clinical characteristics would alter the risk of recording seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a single\u2010center chart review of 324<jats:styled-content style=\"fixed-case\">cVEEG<\/jats:styled-content>studies that were obtained for differential diagnosis of<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s. We examined the type of<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s that prompted<jats:styled-content style=\"fixed-case\">cVEEG<\/jats:styled-content>, associated<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>, and patient characteristics, and whether the target events or seizures were recorded. We performed logistic regression analyses to determine which patient and semiologic features altered the risk of the<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s being seizures, and which patient characteristics altered the risk of recording any seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Target<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s were recorded in 52% (N = 169). Seizures were recorded in 21% (N = 69) of the studies, often unrelated to the<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s (N = 39). When examining only<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s without<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>, only 4% (3\/75) of studies obtained for apnea and 2.1% (1\/48) of studies obtained for oxygen desaturation revealed the target events to be seizures. No studies recorded ictal hypertension (0\/26), hypotension (0\/16), or bradycardia (0\/18). In univariate analysis, there was a decreased risk that the events were seizures when<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s lacked<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>(odds ratio [<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>] 0.23, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.08\u20130.65). The risk was increased when the patient had received an antiseizure medication (2.9, 1.3\u20136.5), the target<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>was apnea (3.5, 1.5\u20138.5), and in particular, apnea with<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>(8.7, 3.7\u201320.8). In adjusted analyses, only apnea with associated<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>independently increased the risk of the<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s being seizures (7.7, 3.2\u201318.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s in the absence of<jats:styled-content style=\"fixed-case\">NAS<\/jats:styled-content>are rarely due to seizures. Ideally,<jats:styled-content style=\"fixed-case\">cVEEG<\/jats:styled-content>should be reserved for children with additional risk factors for seizures, beyond isolated<jats:styled-content style=\"fixed-case\">PVSC<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13276","type":"journal-article","created":{"date-parts":[[2015,12,13]],"date-time":"2015-12-13T04:45:11Z","timestamp":1449981911000},"page":"272-278","source":"Crossref","is-referenced-by-count":13,"title":["Diagnostic yield of continuous video electroencephalography for paroxysmal vital sign changes in pediatric patients"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4853-4952","authenticated-orcid":false,"given":"Louis T.","family":"Dang","sequence":"first","affiliation":[{"name":"Department of Pediatrics and Communicable Diseases Division of Pediatric Neurology C.S. Mott Children's Hospital University of Michigan Ann Arbor Michigan U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren\u00e9e A.","family":"Shellhaas","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Communicable Diseases Division of Pediatric Neurology C.S. Mott Children's Hospital University of Michigan Ann Arbor Michigan U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000170"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31827eda27"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2011.12.009"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1684\/j.1950-6945.2001.tb00380.x","article-title":"Autonomic symptoms during epileptic seizures","volume":"3","author":"Baumgartner C","year":"2001","journal-title":"Epileptic Disord"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.69.5.583"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1979.tb08215.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2012.04.001"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.70.1.87"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1984.04050140071027"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1988.tb37268.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.64.3.357"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-3798(98)80018-4"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/155005940303400406"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000166"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31823e96d7"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000249179.02171.bd"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0013-9580.2005.22504.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0000000000000165"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318211c19e"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.086314"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1988.tb03715.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22345"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13276","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13276","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.13276","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13276","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T01:01:45Z","timestamp":1718240505000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,12]]},"references-count":22,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/epi.13276"],"URL":"https:\/\/doi.org\/10.1111\/epi.13276","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,12]]}}}