{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T12:24:41Z","timestamp":1779020681158,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T00:00:00Z","timestamp":1451520000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["HEALTH\u2010F5\u20102009\u20104.2\u20101"],"award-info":[{"award-number":["HEALTH\u2010F5\u20102009\u20104.2\u20101"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004963","name":"Seventh Framework Programme","doi-asserted-by":"publisher","award":["241479"],"award-info":[{"award-number":["241479"]}],"id":[{"id":"10.13039\/501100004963","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the seizure response rate to lidocaine in a large cohort of infants who received lidocaine as second\u2010 or third\u2010line antiepileptic drug (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>) for neonatal seizures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Full\u2010term (n = 319) and preterm (n = 94) infants, who received lidocaine for neonatal seizures confirmed on amplitude\u2010integrated EEG (aEEG), were studied retrospectively (January 1992\u2013December 2012). Based on <jats:styled-content style=\"fixed-case\">aEEG<\/jats:styled-content> findings, the response was defined as good (&gt;4 h no seizures, no need for rescue medication); intermediate (0\u20132 h no seizures, but rescue medication needed after 2\u20134 h); or no clear response (rescue medication needed &lt;2 h).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Lidocaine had a good or intermediate effect in 71.4%. The response rate was significantly lower in preterm (55.3%) than in full\u2010term infants (76.1%, p &lt; 0.001). In full\u2010term infants the response to lidocaine was significantly better than midazolam as second\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> (21.4% vs. 12.7%, p = 0.049), and there was a trend for a higher response rate as third\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> (67.6% vs. 57%, p = 0.086). Both lidocaine and midazolam had a higher response rate as third\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> than as second\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> (p &lt; 0.001). Factors associated with a good response to lidocaine were the following: higher gestational age, longer time between start of first seizure and administration of lidocaine, lidocaine as third\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>, use of new lidocaine regimens, diagnosis of stroke, use of digital <jats:styled-content style=\"fixed-case\">aEEG<\/jats:styled-content>, and hypothermia. Multivariable analysis of seizure response to lidocaine included lidocaine as second\u2010 or third\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> and seizure etiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Seizure response to lidocaine was seen in ~70%. The response rate was influenced by gestational age, underlying etiology, and timing of administration. Lidocaine had a significantly higher response rate than midazolam as second\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>, and there was a trend for a higher response rate as third\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>. Both lidocaine and midazolam had a higher response rate as third\u2010line compared to second\u2010line <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>, which could be due to a pharmacologic synergistic mechanism between the two drugs.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13286","type":"journal-article","created":{"date-parts":[[2015,12,31]],"date-time":"2015-12-31T09:06:42Z","timestamp":1451552802000},"page":"233-242","source":"Crossref","is-referenced-by-count":55,"title":["Lidocaine response rate in <scp>aEEG<\/scp>\u2010confirmed neonatal seizures: Retrospective study of 413 full\u2010term and preterm infants"],"prefix":"10.1111","volume":"57","author":[{"given":"Lauren C.","family":"Weeke","sequence":"first","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona C.","family":"Toet","sequence":"additional","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda G. M.","family":"van Rooij","sequence":"additional","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floris","family":"Groenendaal","sequence":"additional","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geraldine B.","family":"Boylan","sequence":"additional","affiliation":[{"name":"Irish Centre for Fetal and Neonatal Translational Research University College Cork Cork Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronit M.","family":"Pressler","sequence":"additional","affiliation":[{"name":"Section of Clinical Neurosciences UCL \u2013 Institute of Child Health London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Hellstr\u00f6m\u2010Westas","sequence":"additional","affiliation":[{"name":"Department of Women's and Children's Health Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel P. H.","family":"van den Broek","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda S.","family":"de Vries","sequence":"additional","affiliation":[{"name":"Department of Neonatology Wilhelmina Children's Hospital University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.4.542"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807303072"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emc.2010.08.005"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-0136"},{"key":"e_1_2_8_6_1","first-page":"CD004218","article-title":"Anticonvulsants for neonates with seizures","volume":"18","author":"Booth D","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2009.01659.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2011.11.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000106944.59990.E6"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1988.tb10602.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1992.tb12075.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apa.12311"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-006-0136-x"},{"key":"e_1_2_8_14_1","volume-title":"Neonatal Seizures; Effects of lidocaine on seizures in the neonatal period","author":"Radvanyi\u2010Bouvet MF","year":"1990"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199007000-00003"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073807299858"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2012-302678"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/11589160-000000000-00000"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.086314"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-012-0004-y"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073810384263"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/fn.86.3.F165"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152891.58694.71"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.11.005"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199908123410704"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb02753.x"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002826-199619020-00005"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000368180"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03401.x"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430767"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13286","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13286","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.13286","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13286","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T17:46:07Z","timestamp":1692294367000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,31]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2016,2]]}},"alternative-id":["10.1111\/epi.13286"],"URL":"https:\/\/doi.org\/10.1111\/epi.13286","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,31]]}}}