{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T22:21:31Z","timestamp":1771885291489,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Ministry of University and Research (MIUR)","award":["RBFR08VABD"],"award-info":[{"award-number":["RBFR08VABD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,3]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>To compare heart rate variability (HRV<\/jats:styled-content>) parameters in newly diagnosed and untreated temporal lobe epilepsy (TLE<\/jats:styled-content>) between the interictal, preictal, ictal, and postictal states.<\/jats:p><\/jats:sec>Methods<\/jats:title>HRV<\/jats:styled-content> parameters were extracted from single\u2010lead electrocardiography data collected during video\u2013electroencephalography (EEG<\/jats:styled-content>) recordings from 14 patients with newly diagnosed TLE<\/jats:styled-content> in a resting, awake, and supine state. HRV<\/jats:styled-content> parameters in the time and frequency domains included low frequency (LF<\/jats:styled-content>), high frequency (HF<\/jats:styled-content>), standard deviation of all consecutive R wave intervals (SDNN<\/jats:styled-content>), and square root of the mean of the sum of the squares of differences between adjacent R wave intervals (RMSSD<\/jats:styled-content>). Cardiovagal index (CVI<\/jats:styled-content>), cardiosympathetic index (CSI<\/jats:styled-content>), and approximate entropy (ApEn) were also studied.<\/jats:p><\/jats:sec>Results<\/jats:title>Frequency domain analysis showed significantly higher preictal, ictal, and postictal LF<\/jats:styled-content>\/HF<\/jats:styled-content> ratio compared to the interictal state. Similarly, the LF<\/jats:styled-content> component increased progressively and was significantly higher during the ictal state compared to interictal and preictal states. RR<\/jats:styled-content> interval values were lower in the ictal state compared to basal and preictal states and in the postictal state compared to the preictal state. Interictal RMSSD<\/jats:styled-content> was significantly higher compared to all other states, and ictal SDNN<\/jats:styled-content> was significantly higher compared to all other states. Ictal CSI<\/jats:styled-content> was significantly higher compared to preictal and interictal states, whereas preictal CVI<\/jats:styled-content> was lower than in basal and ictal states. In addition, ictal ApEn was significantly lower than interictal and preictal ApEn. Interictal CVI<\/jats:styled-content> was lower in left TLE<\/jats:styled-content> compared to right TLE<\/jats:styled-content>. In addition, in left TLE<\/jats:styled-content>, ictal CVI<\/jats:styled-content> was higher than interictal CVI<\/jats:styled-content>, whereas in right TLE<\/jats:styled-content>, CVI<\/jats:styled-content> was lower in the preictal state compared to all other states.<\/jats:p><\/jats:sec>Significance<\/jats:title>Our data suggest an ictal sympathetic overdrive with partial recovery in the postictal state. Higher sympathetic tone and vagal tone imbalance may induce early autonomic dysfunction and increase cardiovascular risk in patients affected by TLE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13309","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T09:11:04Z","timestamp":1453885864000},"page":"418-426","source":"Crossref","is-referenced-by-count":48,"title":["Heart rate variability in untreated newly diagnosed temporal lobe epilepsy: Evidence for ictal sympathetic dysregulation"],"prefix":"10.1111","volume":"57","author":[{"given":"Andrea","family":"Romigi","sequence":"first","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"},{"name":"IRCCS Neuromed Sleep Medicine Centre Pozzilli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Albanese","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"},{"name":"IRCCS Neuromed Sleep Medicine Centre Pozzilli Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Placidi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Izzi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola B.","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"},{"name":"Santa Lucia Foundation Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Marchi","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Liguori","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoletta","family":"Campagna","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Duggento","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention Medical Physics Section University of Rome \u201cTor Vergata,\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Canichella","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention Medical Physics Section University of Rome \u201cTor Vergata,\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Ricciardo Rizzo","sequence":"additional","affiliation":[{"name":"Department of Systems Medicine Neurophysiopathology Unit Sleep Medicine Centre Tor Vergata University and Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Guerrisi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention Medical Physics Section University of Rome \u201cTor Vergata,\u201d Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria G.","family":"Marciani","sequence":"additional","affiliation":[{"name":"Department of Neuroscience \u201cTor Vergata,\u201d University Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Toschi","sequence":"additional","affiliation":[{"name":"Department of Biomedicine and Prevention Medical Physics Section University of Rome \u201cTor Vergata,\u201d Rome Italy"},{"name":"Department of Radiology Athinoula A. 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