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We used resting\u2010state functional magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content>) to examine the functional connectivity between the cerebellum and cerebrum in a Chinese family with <jats:styled-content style=\"fixed-case\">BAFME<\/jats:styled-content> for the first time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eleven adults with <jats:styled-content style=\"fixed-case\">BAFME<\/jats:styled-content> and 15 matched healthy controls underwent resting\u2010state blood oxygen level\u2013dependent (<jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">fMRI<\/jats:styled-content> scanning. The cerebellar seeds, including the bilateral crus I, lobule <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content>, lobule <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content>b, and lobule IV&amp;V, were defined a priori. Next, regional time courses were obtained for each individual by averaging the <jats:styled-content style=\"fixed-case\">BOLD<\/jats:styled-content> time series over all voxels in each seed region. Then, seed\u2010based functional connectivity z\u2010maps were produced by computing Pearson's correlation coefficients (converted to z\u2010scores by Fisher transformation) between each seed signal and the time series from all other voxels within the entire brain. Finally, a second\u2010level random\u2010effect two\u2010sample <jats:italic>t<\/jats:italic>\u2010test was performed on the individual z\u2010maps in a voxel\u2010wise manner.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reduced functional connectivity of the right cerebellar crus I with the left middle frontal gyrus and right cerebellar lobule <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> was observed in the default network of <jats:styled-content style=\"fixed-case\">BAFME<\/jats:styled-content>. Enhanced functional connectivity of the left cerebellar lobule <jats:styled-content style=\"fixed-case\">VIII<\/jats:styled-content> with the bilateral middle temporal gyri, right putamen, and left cerebellar crus I was found in the dorsal attention network of <jats:styled-content style=\"fixed-case\">BAFME<\/jats:styled-content>. Enhanced functional connectivity between the left cerebellar lobule <jats:styled-content style=\"fixed-case\">VII<\/jats:styled-content>b and right frontal pole was found in the control network of <jats:styled-content style=\"fixed-case\">BAFME<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Altered cerebellar\u2010cerebral functional connectivity may contribute to the understanding of the nosogenesis of <jats:styled-content style=\"fixed-case\">BAFME<\/jats:styled-content> and explain the cognitive dysfunction in this Chinese family with <jats:styled-content style=\"fixed-case\">BAFME<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13372","type":"journal-article","created":{"date-parts":[[2016,4,2]],"date-time":"2016-04-02T17:50:33Z","timestamp":1459619433000},"page":"941-948","source":"Crossref","is-referenced-by-count":24,"title":["Altered cerebellar\u2010cerebral functional connectivity in benign adult familial myoclonic epilepsy"],"prefix":"10.1111","volume":"57","author":[{"given":"Lili","family":"Long","sequence":"first","affiliation":[{"name":"Department of Neurology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling\u2010Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"College of Mechatronics and Automation National University of Defense Technology Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmin","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Neurology Xiangya Hospital Central South University Changsha Hunan China"},{"name":"Department of Emergency Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Mechatronics and Automation National University of Defense Technology Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Fang","sequence":"additional","affiliation":[{"name":"College of Mechatronics and Automation National University of Defense Technology Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology Fuyang People's Hospital Fuyang Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology Xiangya Hospital Central South University Changsha Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Neurology Fuyang People's Hospital Fuyang Anhui 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