{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T05:02:25Z","timestamp":1791522145788,"version":"4.3.4"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP\u2010102710"],"award-info":[{"award-number":["MOP\u2010102710"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","award":["J3485\u2010B24"],"award-info":[{"award-number":["J3485\u2010B24"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To characterize the interaction between physiologic and pathologic high\u2010frequency oscillations (<jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s) and slow waves during sleep, and to evaluate the practical significance of these interactions by automatically classifying channels as recording from normal or epileptic brain regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We automatically detected <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s in intracerebral electroencephalography (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) recordings of 45 patients. We characterized the interaction between the <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s and the amplitude and phase of automatically detected slow waves during sleep. We computed features associated with <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s, and compared classic features such as rate, amplitude, duration, and frequency to novel features related to the interaction between <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s and slow waves. To quantify the practical significance of the difference in these features we classified the channels as recording from normal\/epileptic regions using logistic regression. We assessed the results in different brain regions to study differences in the <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content> characteristics at the lobar level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found a clear difference in the coupling between the phase of slow waves during sleep and the occurrence of <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s. In channels recording physiologic activity, the <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s tend to occur after the peak of the deactivated state of the slow wave, and in channels with epileptic activity, the <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s occur more often before this peak. This holds for <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s in the ripple (80\u2013250 Hz) and fast ripple (250\u2013500 Hz) bands, and different regions of the brain. When using this interaction to automatically classify channels as recording from normal\/epileptic brain regions, the performance is better than when using other <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content> characteristics. We confirmed differences in the <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content> characteristics in mesiotemporal structures and in the occipital lobe.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We found the association between slow waves and <jats:styled-content style=\"fixed-case\">HFO<\/jats:styled-content>s to be different in normal and epileptic brain regions, emphasizing their different origin. This is also of practical significance, since it improves the separation between channels recording from normal and epileptic brain regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13380","type":"journal-article","created":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T07:26:40Z","timestamp":1463470000000},"page":"869-878","source":"Crossref","is-referenced-by-count":133,"title":["Interaction with slow waves during sleep improves discrimination of physiologic and pathologic high\u2010frequency oscillations (80\u2013500 Hz)"],"prefix":"10.1111","volume":"57","author":[{"given":"Nicol\u00e1s","family":"von Ellenrieder","sequence":"first","affiliation":[{"name":"Montreal Neurological Institute and Hospital McGill University Montreal Qu\u00e9bec Canada"},{"name":"LEICI CONICET\u2014National University of La Plata La Plata Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Frauscher","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital McGill University Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Dubeau","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital McGill University Montreal Qu\u00e9bec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Gotman","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute and Hospital McGill University Montreal Qu\u00e9bec 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