{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:49:28Z","timestamp":1787014168927,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["506\/13"],"award-info":[{"award-number":["506\/13"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,6]]},"abstract":"Summary<\/jats:title>\n \n Our aim was to evaluate the effects of valproic acid (\n VPA<\/jats:styled-content>\n ) on the function of the placental barrier in vivo, in pregnant mice. Studies were conducted on gestational days 12.5 (mid\u2010gestation) or 17.5 (late gestation), following intraperitoneal treatment with 200\u00a0mg\/kg\n VPA<\/jats:styled-content>\n or the vehicle. Indocyanine green (\n ICG<\/jats:styled-content>\n ; 0.167\u00a0mg, i.v.) was used as a marker for the placental barrier permeability. Transporter expression was evaluated by quantitative \u2010\n PCR<\/jats:styled-content>\n .\n VPA<\/jats:styled-content>\n treatment was associated with a 40% increase (p\u00a0<\u00a00.05) in accumulation of\n ICG<\/jats:styled-content>\n in maternal liver in mid\u2010pregnancy and a decrease by one fifth (p\u00a0<\u00a00.05) in late pregnancy. Ex vivo,\n VPA<\/jats:styled-content>\n treatment led to a 20% increase (p\u00a0<\u00a00.05) in fetal\n ICG<\/jats:styled-content>\n emission in mid\u2010pregnancy. Also in mid\u2010pregnancy, the placental expression of the\n L<\/jats:sc>\n \u2010type amino acid transporter, the organic anion\u2013transporting polypeptide (Oatp)4a1 (thyroid hormone transporter), and the reduced folate carrier was lower in\n VPA<\/jats:styled-content>\n \u2010treated mice (p\u00a0<\u00a00.05). In late pregnancy, hepatic Oatp4a1 levels were 40% less than in controls (p\u00a0>\u00a00.05). The observed changes in placental transporter expression and function support further research into the potential role of the placenta in the adverse pregnancy outcomes of\n VPA<\/jats:styled-content>\n . Near\u2010infrared imaging provides a noninvasive, nonradioactive tool for future studies on the effects of epilepsy and antiepileptic drugs on tissue transport functions.\n <\/jats:p>","DOI":"10.1111\/epi.13392","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T09:26:12Z","timestamp":1462353972000},"source":"Crossref","is-referenced-by-count":20,"title":["Effects of valproic acid on the placental barrier in the pregnant mouse: Optical imaging and transporter expression studies"],"prefix":"10.1111","volume":"57","author":[{"given":"Michal","family":"Meir","sequence":"first","affiliation":[{"name":"Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameer","family":"Bishara","sequence":"additional","affiliation":[{"name":"Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniv","family":"Mann","sequence":"additional","affiliation":[{"name":"Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiran","family":"Udi","sequence":"additional","affiliation":[{"name":"Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Portnoy","sequence":"additional","affiliation":[{"name":"Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miri","family":"Shmuel","sequence":"additional","affiliation":[{"name":"Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Eyal","sequence":"additional","affiliation":[{"name":"Institute for Drug Research School of Pharmacy The Hebrew University of Jerusalem Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13021"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13037"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00374"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp300472y"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.11.017"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2011.02.002"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9254-z"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9752-6"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.59.5.1269"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706830"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20040414"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90081-X"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2008.06.015"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100556"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318250d824"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.112.049718"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1964.tb02043.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13392","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13392","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T12:19:36Z","timestamp":1695557976000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13392"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,3]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1111\/epi.13392"],"URL":"https:\/\/doi.org\/10.1111\/epi.13392","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,3]]}}}