{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:05:43Z","timestamp":1790913943802,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T00:00:00Z","timestamp":1464825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>To investigate whether the magnetoencephalography (MEG<\/jats:styled-content>) single moving dipole (SMD<\/jats:styled-content>) method could delineate the epileptic zone of focal cortical dysplasia (FCD<\/jats:styled-content>) at the bottom of sulcus (FCDB<\/jats:styled-content>).<\/jats:p><\/jats:sec>Methods<\/jats:title>We retrospectively analyzed 17 children (11 male; mean age 8.8 years, range 3\u201317 years) with FCD<\/jats:styled-content> type II<\/jats:styled-content> who underwent epilepsy surgery. We compared spatial congruence between the following: (1) MEG<\/jats:styled-content> cluster and FCDB<\/jats:styled-content> and (2) MEG<\/jats:styled-content> cluster and FCD<\/jats:styled-content> at the brain surface (FCDS<\/jats:styled-content>). We measured the volume and depth of magnetic resonance imaging (MRI<\/jats:styled-content>)\u2013visible lesions to investigate whether they affect spatial congruence between MEG<\/jats:styled-content> cluster and MRI<\/jats:styled-content>\u2010visible lesion.<\/jats:p><\/jats:sec>Results<\/jats:title>Eight children had FCDB<\/jats:styled-content> and the other nine children had FCDS<\/jats:styled-content>. The volume of MRI<\/jats:styled-content>\u2010visible lesions for FCDB<\/jats:styled-content> ranged from 1,632 to 4,707 mm3<\/jats:sup> (mean \u00b1 standard deviation [SD<\/jats:styled-content>] 3,095 \u00b1 1,211 mm3<\/jats:sup>). The depth of FCDB<\/jats:styled-content> ranged from 19 to 33 mm (mean \u00b1 SD 26 \u00b1 4 mm). The volume of MRI<\/jats:styled-content>\u2010visible lesion for FCDS<\/jats:styled-content> ranged from 2,375 to 57,331 mm3<\/jats:sup> (15,470 \u00b1 18,455 mm3<\/jats:sup>). There was a tendency for a smaller volume of MRI<\/jats:styled-content>\u2010visible lesion for FCDB<\/jats:styled-content>, relative to FCDS<\/jats:styled-content>(p = 0.079). In FCDB<\/jats:styled-content>, six children showed clusters of MEG<\/jats:styled-content> dipoles and two children showed scattered MEG<\/jats:styled-content> dipoles for interictal spikes. The spatial congruence between the MEG<\/jats:styled-content> result and FCDB<\/jats:styled-content> was partially overlapping in four children and discordant in another four children. In FCDS<\/jats:styled-content>, eight children had MEG<\/jats:styled-content> cluster and one child had MEG<\/jats:styled-content> scatter alone. The spatial congruence between MEG<\/jats:styled-content> result and FCDS<\/jats:styled-content> was overlapping in eight of nine children (fully two; partially six) and discordant in one of nine children. Fifteen children (88%; FCDB<\/jats:styled-content> eight; FCDS<\/jats:styled-content> seven) became seizure\u2010free after resective surgery. MEG<\/jats:styled-content> spike dipole resection ratio in the cluster ranged from 4\u2013100% (mean 67%) in 6 FCDB<\/jats:styled-content> and 23\u201399% (mean 77%) in 8 FCDS<\/jats:styled-content>.<\/jats:p><\/jats:sec>Significance<\/jats:title>The SMD<\/jats:styled-content> method may drift MEG<\/jats:styled-content> spike dipoles for FCDB<\/jats:styled-content>. Lesionectomy can control seizures for four of eight patients in FCDB<\/jats:styled-content> despite the remote MEG<\/jats:styled-content> dipoles. The FCDB<\/jats:styled-content> or FCDS<\/jats:styled-content> partially overlapped with MEG<\/jats:styled-content> cluster may have an extending\/invisible epileptogenic zone consecutive to the MRI<\/jats:styled-content>\u2010visible lesion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13399","type":"journal-article","created":{"date-parts":[[2016,6,2]],"date-time":"2016-06-02T12:53:15Z","timestamp":1464871995000},"page":"1169-1178","source":"Crossref","is-referenced-by-count":22,"title":["Remote MEG<\/scp> dipoles in focal cortical dysplasia at bottom of sulcus"],"prefix":"10.1111","volume":"57","author":[{"given":"Midori","family":"Nakajima","sequence":"first","affiliation":[{"name":"Division of Neurology The Hospital for Sick Children Toronto Ontario Canada"},{"name":"Department of Pediatrics Graduate School of Medicine Hokkaido University Sapporo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elysa","family":"Widjaja","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Baba","sequence":"additional","affiliation":[{"name":"Division of Neurology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosuke","family":"Sato","sequence":"additional","affiliation":[{"name":"Division of Neurology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuhei","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Division of Neurology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Tabei","sequence":"additional","affiliation":[{"name":"Division of Neurology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayaka","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Division of Neurology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Division of Neurology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Holowka","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Ochi","sequence":"additional","affiliation":[{"name":"Division of Neurology The Hospital for Sick Children Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"O. 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