{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T05:22:28Z","timestamp":1785734548870,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Scrub typhus is an emerging infection, and there is little information about status epilepticus (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>) in scrub typhus. We report the clinical spectrum and outcome of <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> in scrub typhus. In a 3\u2010year prospective hospital\u2010based observational study, all scrub typhus patients with <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> were included. Scrub typhus was diagnosed by immunochromatography assay. <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> was defined if convulsions lasted longer than 5 min. The patients' demographic, clinical, computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>), magnetic resonance imaging (<jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content>), and electroencephalography (<jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content>) findings were noted. Response to antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) and outcome at 1 month and 1 year were recorded. Between 2012 and 2014, there were 66 patients with scrub typhus admitted with central nervous system (CNS) involvement, 10 (15.2%) of whom had <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> (generalized convulsions in 5, secondary generalized in one). The median age of the patients was 34 (range 18\u201371) years and seven were female. The duration of <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> ranged between 10 min and 48 h. <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> responded to one <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> in five patients, two <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s in three patients, and more than two <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s in two patients. Cranial <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> findings were normal. All patients recovered completely with doxycycline by 1 month and <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> was withdrawn by 8 months in all. Although 15% patients with scrub typhus may have <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>, they have good outcome.<\/jats:p>","DOI":"10.1111\/epi.13412","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T18:56:52Z","timestamp":1464116212000},"source":"Crossref","is-referenced-by-count":19,"title":["Status epilepticus in scrub typhus"],"prefix":"10.1111","volume":"57","author":[{"given":"Jayantee","family":"Kalita","sequence":"first","affiliation":[{"name":"Department of Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita E.","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjeev K.","family":"Bhoi","sequence":"additional","affiliation":[{"name":"Department of Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Usha K.","family":"Misra","sequence":"additional","affiliation":[{"name":"Department of Neurology Sanjay Gandhi Post Graduate Institute of Medical Sciences Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308722"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.12.012"},{"key":"e_1_2_8_4_1","first-page":"57","article-title":"Meningoencephalitis, myocarditis and disseminated intravascular coagulation in a patient with scrub typhus","volume":"32","author":"Ben RJ","year":"1999","journal-title":"J Microbiol Immunol Infect"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049475513512646"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.51.6214"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/tropej\/fms030"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01556.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-009-5298-9"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0972-5229.136074"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000288178.91614.5d"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/13550280802266523"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0987-7053(00)00203-3"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.02.012"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2009.06.003"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13412","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:20:09Z","timestamp":1696339209000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,24]]},"references-count":14,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1111\/epi.13412"],"URL":"https:\/\/doi.org\/10.1111\/epi.13412","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,24]]}}}