{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:23:46Z","timestamp":1790346226142,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T00:00:00Z","timestamp":1465776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,8]]},"abstract":"Summary<\/jats:title>Leucine\u2010rich glioma inactived\u20101 (LGI<\/jats:styled-content>1) antibodies are associated with limbic encephalitis and distinctive seizure types, which are typically immunotherapy\u2010responsive. Although nonspecific electroencephalography (EEG<\/jats:styled-content>) abnormalities are commonly seen, specific EEG<\/jats:styled-content> characteristics are not currently understood to be useful for suspecting the clinical diagnosis. Based on initial observations in two patients, we analyzed the clinical features and EEG<\/jats:styled-content> recordings in a larger series of patients (n = 9) and describe a novel ictal pattern that can suggest the diagnosis of LGI<\/jats:styled-content>1\u2010antibody\u2013mediated encephalitis, even in the absence of typical clinical features. As expected, psychiatric and cognitive symptoms were common, as were tonic seizures associated with EEG<\/jats:styled-content> electrodecremental events (often with the so\u2010called faciobrachial dystonic semiology). Remarkably, in five patients, a near absence of interictal epileptiform discharges contrasted with frequent subclinical temporal lobe seizures, at times triggered by hyperventilation. This latter EEG<\/jats:styled-content> pattern may facilitate early diagnosis of this serious but potentially treatable condition.<\/jats:p>","DOI":"10.1111\/epi.13436","type":"journal-article","created":{"date-parts":[[2016,6,13]],"date-time":"2016-06-13T09:25:44Z","timestamp":1465809944000},"source":"Crossref","is-referenced-by-count":54,"title":["Subclinical temporal EEG<\/scp> seizure pattern in LGI<\/scp>1\u2010antibody\u2013mediated encephalitis"],"prefix":"10.1111","volume":"57","author":[{"given":"Claude","family":"Steriade","sequence":"first","affiliation":[{"name":"University Health Network Division of Neurology Department of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed M.","family":"Mirsattari","sequence":"additional","affiliation":[{"name":"Department of Clinical Neurological Sciences London Health Sciences Centre University Hospital Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J.","family":"Murray","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Medicine Sunnybrook Health Sciences Centre University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wennberg","sequence":"additional","affiliation":[{"name":"University Health Network Division of Neurology Department of Medicine University of Toronto Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000122648.19196.02"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh077"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq213"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70137-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22307"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182152808"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02287.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000326572.93762.51"},{"key":"e_1_2_6_10_1","first-page":"2241","article-title":"Reply from the authors \u2013 tonic seizures: a diagnostic clue of anti\u2010LGI1 encephalitis?","volume":"77","author":"Andrade D","year":"2011","journal-title":"Neurology"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(81)90008-0"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2006.07.137"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3506-13.2013"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10280"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng832"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13436","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T13:02:09Z","timestamp":1694955729000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,13]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/epi.13436"],"URL":"https:\/\/doi.org\/10.1111\/epi.13436","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,13]]}}}