{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:24:18Z","timestamp":1793384658707,"version":"4.5.0"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T00:00:00Z","timestamp":1475020800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Effective contraception enables women with epilepsy (<jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content>) to plan their pregnancies and improve outcomes for themselves and their children. Although popular among all women, complex drug interactions limit the efficacy and safety of oral contraceptives (<jats:styled-content style=\"fixed-case\">OC<\/jats:styled-content>s) for <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content>. We sought to explore the safety, acceptability, and pharmacokinetic impact of a progestin\u2010containing intrauterine device (<jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content>) in <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We enrolled 20 women with well\u2010controlled epilepsy and a stable antiepileptic drug (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>) regimen and who were initiating a progestin\u2010containing <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> (levonorgestrel 52 mg) in a prospective, observational study. For each <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>, we compared the trough concentration before <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> insertion to the trough concentration 3 weeks, and 3 and 6 months later. Participants recorded seizures in a daily paper diary. We compared seizures that occurred during the month before <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> insertion to those occurring in the 6 months thereafter. Participants completed an acceptability questionnaire at 3 and 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Participants\u2019 average age was 28 years; 60% were nulligravid. They reported a history of multiple seizure types. During the baseline month, 75% were seizure\u2010free and the remainder reported between one and three seizures. Fourteen received monotherapy and six received polytherapy. Lamotrigine use was most common (n = 12). <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> trough concentrations remained stable during the 6 months after <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> insertion, without clinically meaningful deviations from baseline. Diary data showed that seizure frequency worsened in 3, and remained unchanged in 13 and improved in 4 after <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> insertion. Subjectively, no participant believed the <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> worsened her seizure control. All participants were either somewhat or very satisfied with the <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> throughout the study. All participants continued the <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> use at 6 months. No pregnancies occurred.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This pilot study suggests that the progestin\u2010containing <jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> is a safe and acceptable long\u2010acting contraceptive for <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13559","type":"journal-article","created":{"date-parts":[[2016,9,28]],"date-time":"2016-09-28T12:00:14Z","timestamp":1475064014000},"page":"1843-1848","source":"Crossref","is-referenced-by-count":21,"title":["Women with epilepsy initiating a progestin <scp>IUD<\/scp>: A prospective pilot study of safety and acceptability"],"prefix":"10.1111","volume":"57","author":[{"given":"Anne R.","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Columbia University Medical Center New York New York U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heva J.","family":"Saadatmand","sequence":"additional","affiliation":[{"name":"Columbia University College of Physicians and Surgeons New York New York U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Pack","sequence":"additional","affiliation":[{"name":"Department of Neurology Columbia University Medical Center New York New York U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2009.04.026"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02917.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000076485.09353.7A"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2007.11.017"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.10105.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000001134"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1783\/147118902101195992"},{"key":"e_1_2_8_9_1","first-page":"1","volume-title":"US Medical Eligibility Criteria for Contraceptive Use","author":"Curtis K","year":"2016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13320"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02539.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.00997.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13559","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13559","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13559","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:06:14Z","timestamp":1695477974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13559"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,28]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1111\/epi.13559"],"URL":"https:\/\/doi.org\/10.1111\/epi.13559","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,28]]}}}