{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T18:01:34Z","timestamp":1775671294522,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T00:00:00Z","timestamp":1474848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,11]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>Oxcarbazepine (OXC<\/jats:styled-content>) is a widely used antiepileptic drug for the treatment of partial seizures that was developed through structural variation of carbamazepine. Although OXC<\/jats:styled-content> has a lower risk of cutaneous adverse drug reactions (cADR<\/jats:styled-content>s) than carbamazepine, cADR<\/jats:styled-content>s ranging from maculopapular eruption (MPE<\/jats:styled-content>) to the more severe Stevens\u2010Johnson syndrome and toxic epidermal necrolysis still limit the use of OXC<\/jats:styled-content> in some patients. A few human leukocyte antigen (HLA<\/jats:styled-content>)\u2013related genetic risk factors for carbamazepine\u2010induced cADR<\/jats:styled-content>s have been identified. However, the HLA<\/jats:styled-content>\u2010related genetic risk factors associated with OXC<\/jats:styled-content>\u2010induced cADR<\/jats:styled-content>s are unknown.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 40 patients who experienced OXC<\/jats:styled-content>\u2010induced MPE<\/jats:styled-content> and 70 patients who were tolerant to OXC<\/jats:styled-content> treatment were included in the study. Genomic DNA<\/jats:styled-content> was extracted from the peripheral blood of these patients, and high\u2010resolution HLA<\/jats:styled-content> genotyping was performed.<\/jats:p><\/jats:sec>Results<\/jats:title>The HLA<\/jats:styled-content>\u2010B*40:02 and HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1*04:03 alleles were significantly associated with OXC<\/jats:styled-content>\u2010induced MPE<\/jats:styled-content> compared with the OXC<\/jats:styled-content>\u2010tolerant group (odds ratio [OR<\/jats:styled-content>] 4.33, p = 0.018 and OR<\/jats:styled-content> 14.64, p = 0.003, respectively) and the general Korean population (OR<\/jats:styled-content> 4.04, p = 0.001 and OR<\/jats:styled-content> 3.11, p = 0.019, respectively). The HLA<\/jats:styled-content>\u2010B*15:01 genetic frequency was significantly lower in the OXC<\/jats:styled-content>\u2010MPE<\/jats:styled-content> group compared to the OXC<\/jats:styled-content>\u2010tolerant group (OR<\/jats:styled-content> 0.18, p = 0.016) and the Korean population (OR<\/jats:styled-content> 0.22, p = 0.030). The allele frequencies of well\u2010known HLA<\/jats:styled-content>\u2010related risk factors for carbamazepine\u2010induced cADR<\/jats:styled-content>s (HLA<\/jats:styled-content>\u2010B*15:02, A*31:01 and B*15:11) were not different among the three groups.<\/jats:p><\/jats:sec>Significance<\/jats:title>This study is the first to demonstrate an association of HLA<\/jats:styled-content>\u2010B*40:02 and HLA<\/jats:styled-content>\u2010DRB<\/jats:styled-content>1*04:03 with OXC<\/jats:styled-content> hypersensitivity using a large cohort of patients with OXC<\/jats:styled-content>\u2010induced MPE<\/jats:styled-content>. These findings should be confirmed in future studies in different ethnic groups.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13566","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T05:56:38Z","timestamp":1474869398000},"page":"1879-1886","source":"Crossref","is-referenced-by-count":27,"title":["HLA<\/scp>\u2010B*40:02 and DRB<\/scp>1*04:03 are risk factors for oxcarbazepine\u2010induced maculopapular eruption"],"prefix":"10.1111","volume":"57","author":[{"given":"Jangsup","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Neurology Laboratory for Neurotherapeutics Comprehensive Epilepsy Center Biomedical Research Institute Seoul National University Hospital Seoul Korea"},{"name":"Program in Neuroscience Seoul National University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae\u2010Joon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology 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