{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T19:38:29Z","timestamp":1765827509720,"version":"3.37.3"},"reference-count":40,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T00:00:00Z","timestamp":1476316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["N01\u2010ES\u201075558"],"award-info":[{"award-number":["N01\u2010ES\u201075558"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1 UO1 NS 047537\u201001","2 UO1 NS 047537\u201006A1"],"award-info":[{"award-number":["1 UO1 NS 047537\u201001","2 UO1 NS 047537\u201006A1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate whether prepregnancy overweight in women with epilepsy increases their risk for complications during pregnancy and delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study is based on The Norwegian Mother and Child Cohort Study (MoBa) linked to the Medical Birth Registry of Norway. A diagnosis of epilepsy was reported in 706 pregnancies. Overweight was defined as body mass index\u00a0\u2265\u00a025 prepregnancy. Overweight women with epilepsy (n\u00a0=\u00a0259) were compared to normal\u2010weight women with epilepsy (n\u00a0=\u00a0416), and to women without epilepsy with and without overweight (n\u00a0=\u00a030,516 and n\u00a0=\u00a067,977, respectively). The risks of pregnancy and delivery complications were calculated as odds ratios (ORs) with 95% confidence intervals (CIs) adjusted for adverse socioeconomic factors, age, parity, and smoking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Women with epilepsy were more often overweight than women without epilepsy (38.4% vs. 31.3%, p\u00a0&lt;\u00a00.001). The majority of pregnancy and delivery complications were more frequent in overweight women with epilepsy. Compared to overweight women without epilepsy, the risk was increased for cesarean section (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.6, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20132.2, p\u00a0&lt;\u00a00.001), excessive bleeding (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.4, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.0\u20131.8, p\u00a0=\u00a00.04), peripartum anxiety and depressive symptoms (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.9, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.3\u20132.8, p\u00a0&lt;\u00a00.001), small for gestational age children (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.4, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20134.8, p\u00a0=\u00a00.02), and transfer of the infant to a neonatal ward (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.5, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20132.2, p\u00a0=\u00a00.02). Compared to normal\u2010weight women with epilepsy, the risk of cesarean section (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 1.6, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20132.3, p\u00a0&lt;\u00a00.05), gestational hypertension (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.0, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.1\u20133.5, p\u00a0&lt;\u00a00.05), preeclampsia (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.3, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u20134.5, p\u00a0&lt;\u00a00.05), and transfer of the infant to a neonatal ward (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> 2.2, <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.3\u20133.6, p\u00a0&lt;\u00a00.01) was increased.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Prepregnancy overweight in combination with epilepsy entails a strong negative effect on risk of complications during pregnancy and delivery. In women with epilepsy and overweight referral to a nutritionist should be considered when an antiepileptic drug is started as well as when pregnancy is planned. These women should be regarded as a high\u2010risk group.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13573","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T01:37:13Z","timestamp":1476409033000},"page":"1849-1857","source":"Crossref","is-referenced-by-count":8,"title":["Overweight in epilepsy as a risk factor for pregnancy and delivery complications"],"prefix":"10.1111","volume":"57","author":[{"given":"Eivind","family":"Kolstad","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine University of Bergen Bergen Norway"},{"name":"Department of Neurology Haukeland University Hospital Bergen Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyri","family":"Veiby","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine University of Bergen Bergen Norway"},{"name":"Department of Neurology Haukeland University Hospital Bergen 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