{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:15:50Z","timestamp":1790010950648,"version":"4.0.1"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T00:00:00Z","timestamp":1480377600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000226","name":"Ontario Ministry of Health and Long-Term Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010564","name":"Academic Medical Organization of Southwestern Ontario","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008093","name":"Schulich School of Medicine and Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004381","name":"Western University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008958","name":"Lawson Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007775","name":"Universidade Cat\u00f3lica de Bras\u00edlia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008914","name":"Ontario Brain Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine the 30\u2010day risk of hospitalization with hyponatremia associated with carbamazepine, valproic acid (V), phenytoin (P), or topiramate (T) use compared to nonuse in the outpatient setting among older adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted two population\u2010based, retrospective cohort studies in Ontario, Canada, between 2003 and 2015 using administrative health care databases of older adults. The first study compared carbamazepine users to a propensity\u2010score matched group of antiepileptic drug nonusers, whereas the second compared V\u2010P\u2010T users to a propensity\u2010score matched group of antiepileptic nonusers. The primary outcome was hospitalization with hyponatremia within 30 days of an antiepileptic prescription.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline characteristics between matched groups were similar in both cohorts. Carbamazepine use versus nonuse was associated with a higher 30\u2010day risk of hospitalization with hyponatremia (82\/21,191 [0.39%] versus 30\/63,573 [0.05%]; relative risk [RR] 8.20, 95% confidence interval [CI] 5.40\u201312.46). Similarly, V\u2010P\u2010T use versus nonuse was associated with a higher 30\u2010day risk of hospitalization with hyponatremia (34\/20,155 [0.17%] versus 26\/40,310 [0.06%]; RR 2.62, 95% CI 1.57\u20134.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Older adults prescribed carbamazepine and V\u2010P\u2010T have a higher risk of being hospitalized with hyponatremia compared to other adults with similar indicators of baseline health who were not prescribed antiepileptic drugs. Physicians should be mindful of this risk; when a patient presents to a hospital with symptomatic hyponatremia these drugs should be considered as potential causes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13593","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T09:02:45Z","timestamp":1480410165000},"page":"2067-2079","source":"Crossref","is-referenced-by-count":31,"title":["Antiepileptic drugs and hyponatremia in older adults: Two population\u2010based cohort studies"],"prefix":"10.1111","volume":"57","author":[{"given":"Sonja","family":"Gandhi","sequence":"first","affiliation":[{"name":"Department of Epidemiology &amp; Biostatistics Western University London Ontario Canada"},{"name":"Division of Nephrology Department of Medicine Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"McArthur","sequence":"additional","affiliation":[{"name":"Division of Nephrology Department of Medicine Western University London Ontario Canada"},{"name":"Institute for Clinical Evaluative Sciences London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad M.","family":"Mamdani","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences London Ontario Canada"},{"name":"Li Ka Shing Knowledge Institute of St. Michael's Hospital Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel G.","family":"Hackam","sequence":"additional","affiliation":[{"name":"Institute for Clinical Evaluative Sciences London Ontario Canada"},{"name":"Division of Clinical Pharmacology Department of Medicine Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"McLachlan","sequence":"additional","affiliation":[{"name":"Epilepsy Program Department of Clinical Neurological Sciences Western University London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew A.","family":"Weir","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; 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