{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:08:54Z","timestamp":1790197734769,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T00:00:00Z","timestamp":1487808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Children with myoclonic astatic epilepsy (MAE; Doose syndrome) whose seizures do not respond immediately to standard antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) are at high risk of developing an epileptic encephalopathy with cognitive decline. A classic ketogenic diet (<jats:styled-content style=\"fixed-case\">KD<\/jats:styled-content>) is a highly effective alternative to<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s. To date, there are only limited data on the effectiveness of the modified Atkins diet (<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>), which is less restrictive and more compatible with daily life. We report findings from a retrospective study on 30<jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>patients treated with<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four participating centers retrospectively identified all patients with<jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>in whom a<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>had been started before June 2015. Seven children were recruited from a cohort included in an open prospective controlled trial. A retrospective review of all available charts was performed in the other patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty patients (24 boys) were included. Mean age at epilepsy onset was 3.1\u00a0years (range 1.5\u20135.6).<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>was started at a mean age of 4.5\u00a0years (range 2.2\u20139.1) after the children had received an average of six different AEDs (range 2\u201315). Mean<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>observation time was 18.7\u00a0months (range 1.5\u201361.5). Twenty of 30 patients were still on<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>at the end of study (duration range 1.5\u201361.5, mean 18.5\u00a0months).<jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>was stopped without relapse in three patients after sustained seizure freedom for &gt;2\u00a0years. For the other seven cases, ineffectiveness (three patients), loss of efficacy (two), or noncompliance (two) led to termination. No severe adverse effects were noted. By the end of the observation period, 25 (83%) of 30 patients experienced a seizure reduction by \u226550% and 14 (47%) of 30 were seizure\u2010free. None of the evaluated factors differed significantly between the groups of seizure\u2010free and non\u2013seizure\u2010free children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">MAD<\/jats:styled-content>is an effective treatment for<jats:styled-content style=\"fixed-case\">MAE<\/jats:styled-content>. It should be considered as an alternative to<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s or the more restrictive classic ketogenic diet.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13701","type":"journal-article","created":{"date-parts":[[2017,2,23]],"date-time":"2017-02-23T05:06:51Z","timestamp":1487826411000},"page":"657-662","source":"Crossref","is-referenced-by-count":42,"title":["Modified Atkins diet is an effective treatment for children with Doose syndrome"],"prefix":"10.1111","volume":"58","author":[{"given":"Adelheid","family":"Wiemer\u2010Kruel","sequence":"first","affiliation":[{"name":"Epilepsy Centre Kork Clinic for Children and Adolescents Kehl\u2010Kork Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edda","family":"Haberlandt","sequence":"additional","affiliation":[{"name":"Department for Neuropediatrics Children's University Hospital Innsbruck Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Hannover Medical School Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriele","family":"Wohlrab","sequence":"additional","affiliation":[{"name":"Department for Neuropediatrics Children's University Hospital Z\u00fcrich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Bast","sequence":"additional","affiliation":[{"name":"Epilepsy Centre Kork Clinic for Children and Adolescents Kehl\u2010Kork Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0041-6"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(01)00281-9"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-33675"},{"key":"e_1_2_9_5_1","first-page":"39","volume-title":"Long\u2010term evolution of epileptic encephalopathies","author":"Stephani U","year":"2009"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00690.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01186.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2011.12.012"},{"key":"e_1_2_9_9_1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1684\/j.1950-6945.2006.tb00174.x","article-title":"Ketogenic diet in patients with myoclonic\u2010astatic epilepsy","volume":"8","author":"Caraballo RH","year":"2006","journal-title":"Epileptic Disord"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.04.009"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2012.01.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.10.009"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2013.09.032"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00910.x"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12069"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13256"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.10.004"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02774.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2010.12.010"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.102"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03581.x"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2015.09.007"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T16:04:32Z","timestamp":1750003472000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,23]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["10.1111\/epi.13701"],"URL":"https:\/\/doi.org\/10.1111\/epi.13701","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,23]]}}}