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The aim of this systematic review was to identify and evaluate studies reporting on the use of\n                      <jats:styled-content style=\"fixed-case\">LCM<\/jats:styled-content>\n                      in\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a systematic literature search of electronic databases using a combined search strategy from 2008 until October 2016. Using a standardized assessment form, information on the study design, methodologic framework, data sources, efficacy, and adverse events attributed to\n                      <jats:styled-content style=\"fixed-case\">LCM<\/jats:styled-content>\n                      were extracted from each publication and systematically reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 522\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      episodes (51.7% female) in 486 adults and 36 children and adolescents were evaluated with an overall\n                      <jats:styled-content style=\"fixed-case\">LCM<\/jats:styled-content>\n                      efficacy of 57%. Efficacy was comparable between use in nonconvulsive (57%; 82\/145) and generalized\u2010convulsive (61%; 30\/49; p = 0.68)\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      , whereas overall success rate was better in focal motor\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      (92%; 34\/39, p = 0.013; p &lt; 0.001). The efficacy with later positioning of\n                      <jats:styled-content style=\"fixed-case\">LCM<\/jats:styled-content>\n                      decreased from 100% to 20%. The main adverse events during treatment of\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      are dizziness, abnormal vision, diplopia, and ataxia. Overall, lacosamide is well tolerated and has no clinically relevant drug\u2013drug interactions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>\n                      The available data regarding the use of\n                      <jats:styled-content style=\"fixed-case\">LCM<\/jats:styled-content>\n                      in\n                      <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>\n                      are promising, with a success rate of 57%. The strength of\n                      <jats:styled-content style=\"fixed-case\">LCM<\/jats:styled-content>\n                      is the lack of interaction potential and the option for intravenous use in emergency situations requiring rapid uptitration.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.13716","type":"journal-article","created":{"date-parts":[[2017,3,11]],"date-time":"2017-03-11T04:23:12Z","timestamp":1489206192000},"page":"933-950","source":"Crossref","is-referenced-by-count":130,"title":["Lacosamide in status epilepticus: Systematic review of current evidence"],"prefix":"10.1111","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-9915","authenticated-orcid":false,"given":"Adam","family":"Strzelczyk","sequence":"first","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe\u2010University Frankfurt am Main Germany"},{"name":"Epilepsy Center Hessen and Department of 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