{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:14:21Z","timestamp":1790511261058,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,23]],"date-time":"2017-03-23T00:00:00Z","timestamp":1490227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000355","name":"Bupa Foundation","doi-asserted-by":"publisher","award":["BUPA 22094612"],"award-info":[{"award-number":["BUPA 22094612"]}],"id":[{"id":"10.13039\/501100000355","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000765","name":"University College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000765","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Diffusion magnetic resonance imaging (MRI) studies have demonstrated acute white matter changes following prolonged febrile seizures (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>), but their longer\u2010term evolution is unknown. We investigated a population\u2010based cohort to determine white matter diffusion properties 8 years after <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used diffusion tensor imaging (DTI) and applied Tract\u2010Based Spatial Statistics for voxel\u2010wise comparison of white matter microstructure between 26 children with <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> and 27 age\u2010matched healthy controls. Age, gender, handedness, and hippocampal volumes were entered as covariates for voxel\u2010wise analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean duration between the episode of <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> and follow\u2010up was 8.2 years (range 6.7\u20139.6). All children were neurologically normal, and had normal conventional neuroimaging. On voxel\u2010wise analysis, compared to controls, the <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> group had (1) increased fractional anisotropy in early maturing central white matter tracts, (2) increased mean and axial diffusivity in several peripheral white matter tracts and late\u2010maturing central white matter tracts, and (3) increased radial diffusivity in peripheral white matter tracts. None of the tracts had reduced fractional anisotropy or diffusivity indices in the <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>In this homogeneous, population\u2010based sample, we found increased fractional anisotropy in early maturing central white matter tracts and increased mean and axial diffusivity with\/without increased radial diffusivity in several late\u2010maturing peripheral white matter tracts 8 years post\u2010<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>. We propose disruption in white matter maturation secondary to seizure\u2010induced axonal injury, with subsequent neuroplasticity and microstructural reorganization as a plausible explanation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13724","type":"journal-article","created":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T06:51:17Z","timestamp":1490338277000},"page":"772-780","source":"Crossref","is-referenced-by-count":20,"title":["Long\u2010term white matter tract reorganization following prolonged febrile seizures"],"prefix":"10.1111","volume":"58","author":[{"given":"Suresh S.","family":"Pujar","sequence":"first","affiliation":[{"name":"Neurosciences Unit UCL Great Ormond Street Institute of Child Health London United Kingdom"},{"name":"Great Ormond Street Hospital for Children NHS Foundation Trust London United Kingdom"},{"name":"Young Epilepsy Lingfield Surrey United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran K.","family":"Seunarine","sequence":"additional","affiliation":[{"name":"Imaging and Biophysics Unit UCL Great Ormond Street Institute of Child Health London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina M.","family":"Martinos","sequence":"additional","affiliation":[{"name":"Developmental Cognitive Neuroscience Unit UCL Great Ormond Street Institute of Child Health London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G. 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