{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:26:26Z","timestamp":1761513986367},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T00:00:00Z","timestamp":1491177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100001605","name":"Epilepsy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To report the reasons for discontinuation of contraceptive methods by women with epilepsy (<jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>These retrospective data come from a web\u2010based survey regarding the contraceptive practices of 1,144 <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content> in the community, ages 18\u201347 years. We determined the frequencies of contraceptive discontinuations and the reasons for discontinuation. We compared risk ratios for rates of discontinuation among contraceptive methods and categories. We used chi\u2010square analysis to test the independence of discontinuation reasons among the various contraceptive methods and categories and when stratified by antiepileptic drug (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>) categories.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine hundred fifty\u2010nine of 2,393 (40.6%) individual, reversible contraceptive methods were discontinued. One\u2010half (51.8%) of the <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content> who discontinued a method discontinued at least two methods. Hormonal contraception was discontinued most often (553\/1,091, 50.7%) with a risk ratio of 1.94 (1.54\u20132.45, p &lt; 0.0001) compared to intrauterine devices (<jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content>s), the category that was discontinued the least (57\/227, 25.1%). Among all individual methods, the contraceptive patch was stopped most often (79.7%) and the progestin\u2010<jats:styled-content style=\"fixed-case\">IUD<\/jats:styled-content> was stopped the least (20.1%). The top three reasons for discontinuation among all methods were reliability concerns (13.9%), menstrual problems (13.5%), and increased seizures (8.6%). There were significant differences among discontinuation rates and reasons when stratified by <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> category for hormonal contraception but not for any other contraceptive category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Contraception counseling for <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content> should consider the special experience profiles that are unique to this special population on systemic hormonal contraception.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13734","type":"journal-article","created":{"date-parts":[[2017,4,5]],"date-time":"2017-04-05T11:24:41Z","timestamp":1491391481000},"page":"907-914","source":"Crossref","is-referenced-by-count":9,"title":["Reasons for discontinuation of reversible contraceptive methods by women with epilepsy"],"prefix":"10.1111","volume":"58","author":[{"given":"Hannah B.","family":"Mandle","sequence":"first","affiliation":[{"name":"Harvard Neuroendocrine Unit Beth Israel Deaconess Medical Center Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn E.","family":"Cahill","sequence":"additional","affiliation":[{"name":"Harvard Neuroendocrine Unit Beth Israel Deaconess Medical Center Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen M.","family":"Fowler","sequence":"additional","affiliation":[{"name":"Harvard Neuroendocrine Unit Beth Israel Deaconess Medical Center Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. Allen","family":"Hauser","sequence":"additional","affiliation":[{"name":"Gertrude H. Sergievsky Center Mailman School of Public Health Columbia University New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne R.","family":"Davis","sequence":"additional","affiliation":[{"name":"Department of OBGYN Columbia University Medical Center New York New York U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew G.","family":"Herzog","sequence":"additional","affiliation":[{"name":"Harvard Neuroendocrine Unit Beth Israel Deaconess Medical Center Boston Massachusetts U.S.A"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2007.06.008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13320"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200216040-00005"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2007.11.012"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02917.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.06.013"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.34.7.959"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.49.1.47"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02539.x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1586\/ecp.10.3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000344167.78102.f0"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2005.10105.x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-1211(01)00305-9"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000076485.09353.7A"},{"key":"e_1_2_9_16_1","volume-title":"Contraceptive methods women have ever used: United States, 1982\u20132010","author":"Daniels K","year":"2013"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2016.04.020"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13559"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1783\/147118902101195992"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2011.01.021"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.01.007"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2006.12.009"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.12.052"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(86)90028-4"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2016.1243472"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.04.001"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1528-1157.2002.57701.x"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2012.05.010"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70107-7"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182574f39"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(90)90046-X"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2015.05.001"},{"key":"e_1_2_9_33_1","volume-title":"Mirena [package insert]","year":"2015"},{"key":"e_1_2_9_34_1","volume-title":"ParaGard [package insert]","year":"2016"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13734","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T16:55:37Z","timestamp":1694278537000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,3]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/epi.13734"],"URL":"https:\/\/doi.org\/10.1111\/epi.13734","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,3]]}}}