{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:51:11Z","timestamp":1790603471634,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["2012BAI16B01"],"award-info":[{"award-number":["2012BAI16B01"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess heart\u2010rate variability (<jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content>) measures of interictal electrocardiography (<jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content>) for drug\u2010resistant epilepsy and to relate the findings to the outcome of vagus nerve stimulation (<jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content>) treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Time\u2010domain, frequency\u2010domain, and nonlinear analyses were used to analyze preoperative <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> measures in 32 patients with drug\u2010resistant epilepsy who had received <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> implants at the same hospital and 32 healthy age\u2010 and sex\u2010matched control subjects. <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> measurements based on ambulatory 24\u00a0h <jats:styled-content style=\"fixed-case\">ECG<\/jats:styled-content> recordings were analyzed to identify seizure reduction 1\u00a0year after <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> treatment. Responders were defined as having at least 50% seizure reduction 1\u00a0year after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with drug\u2010resistant epilepsy had significantly lower time domain (<jats:styled-content style=\"fixed-case\">SDNN<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> RMSSD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> pNN<\/jats:styled-content>50), frequency domain (<jats:styled-content style=\"fixed-case\">VLF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> LF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HF<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> TP<\/jats:styled-content>), and nonlinear (<jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>1, <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>2) <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> measurements than matched healthy controls. None of the analyzed <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> measures of the responders differed significantly from their controls, whereas those of the nonresponders had significantly lower <jats:styled-content style=\"fixed-case\">RMSSD<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> pNN<\/jats:styled-content>50, <jats:styled-content style=\"fixed-case\">HF<\/jats:styled-content>, and <jats:styled-content style=\"fixed-case\">SD<\/jats:styled-content>1 than the responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>The preoperative <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> indices demonstrate that nonresponders have more pronounced impairment of their cardiac autonomic function than the responders. Presurgical <jats:styled-content style=\"fixed-case\">HRV<\/jats:styled-content> measurements representing parasympathetic cardiac control or vagal tone were significantly associated with the responsiveness to <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content>. Thus the measurements show promise for predicting the reduction of seizure frequency after <jats:styled-content style=\"fixed-case\">VNS<\/jats:styled-content> treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13738","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T13:12:57Z","timestamp":1493125977000},"page":"1015-1022","source":"Crossref","is-referenced-by-count":57,"title":["Heart\u2010rate variability indices as predictors of the response to vagus nerve stimulation in patients with drug\u2010resistant epilepsy"],"prefix":"10.1111","volume":"58","author":[{"given":"Hongyun","family":"Liu","sequence":"first","affiliation":[{"name":"National Engineering Laboratory for Neuromodulation School of Aerospace Engineering Tsinghua University Beijing China"},{"name":"Department of Biomedical Engineering Chinese PLA General Hospital Beijing 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