{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T04:22:26Z","timestamp":1790914946539,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Evaluate the seizure\u2010reduction response and safety of mesial temporal lobe (<jats:styled-content style=\"fixed-case\">MTL<\/jats:styled-content>) brain\u2010responsive stimulation in adults with medically intractable partial\u2010onset seizures of mesial temporal lobe origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects with mesial temporal lobe epilepsy (<jats:styled-content style=\"fixed-case\">MTLE<\/jats:styled-content>) were identified from prospective clinical trials of a brain\u2010responsive neurostimulator (<jats:styled-content style=\"fixed-case\">RNS<\/jats:styled-content> System, NeuroPace). The seizure reduction over years 2\u20136 postimplantation was calculated by assessing the seizure frequency compared to a preimplantation baseline. Safety was assessed based on reported adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 111 subjects with <jats:styled-content style=\"fixed-case\">MTLE<\/jats:styled-content>; 72% of subjects had bilateral <jats:styled-content style=\"fixed-case\">MTL<\/jats:styled-content> onsets and 28% had unilateral onsets. Subjects had one to four leads placed; only two leads could be connected to the device. Seventy\u2010six subjects had depth leads only, 29 had both depth and strip leads, and 6 had only strip leads. The mean follow\u2010up was 6.1\u00a0\u00b1 (standard deviation) 2.2\u00a0years. The median percent seizure reduction was 70% (last observation carried forward). Twenty\u2010nine percent of subjects experienced at least one seizure\u2010free period of 6\u00a0months or longer, and 15% experienced at least one seizure\u2010free period of 1\u00a0year or longer. There was no difference in seizure reduction in subjects with and without mesial temporal sclerosis (<jats:styled-content style=\"fixed-case\">MTS<\/jats:styled-content>), bilateral <jats:styled-content style=\"fixed-case\">MTL<\/jats:styled-content> onsets, prior resection, prior intracranial monitoring, and prior vagus nerve stimulation. In addition, seizure reduction was not dependent on the location of depth leads relative to the hippocampus. The most frequent serious device\u2010related adverse event was soft tissue implant\u2010site infection (overall rate, including events categorized as device\u2010related, uncertain, or not device\u2010related: 0.03 per implant year, which is not greater than with other neurostimulation devices).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Brain\u2010responsive stimulation represents a safe and effective treatment option for patients with medically intractable epilepsy, including patients with unilateral or bilateral <jats:styled-content style=\"fixed-case\">MTLE<\/jats:styled-content> who are not candidates for temporal lobectomy or who have failed a prior <jats:styled-content style=\"fixed-case\">MTL<\/jats:styled-content> resection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13740","type":"journal-article","created":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T12:22:21Z","timestamp":1491913341000},"page":"994-1004","source":"Crossref","is-referenced-by-count":296,"title":["Brain\u2010responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy"],"prefix":"10.1111","volume":"58","author":[{"given":"Eric B.","family":"Geller","sequence":"first","affiliation":[{"name":"Saint Barnabas Health Livingston New Jersey U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara L.","family":"Skarpaas","sequence":"additional","affiliation":[{"name":"NeuroPace, Inc. 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