{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:42:47Z","timestamp":1790196167150,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Hypothalamic hamartoma may present with epilepsy, specifically gelastic or dacrystic seizures, or endocrine dysfunction, commonly precocious puberty. The epilepsy in many patients is drug resistant, and has a high association with progressive cognitive, learning and behavioral difficulty. Medical treatment of seizures remains problematic, with many resistant to drug treatment. Surgical resection, or disconnection of the hamartoma provides the optimal chance of seizure control but with a relatively high risk of endocrine dysfunction, the result of interference with the hypothalamic\u2010pituitary axis in many. Careful assessment and monitoring by specialist centers with discussion of optimal intervention is required for individual cases.<\/jats:p>","DOI":"10.1111\/epi.13758","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T20:35:26Z","timestamp":1496867726000},"page":"16-21","source":"Crossref","is-referenced-by-count":28,"title":["Medical management and antiepileptic drugs in hypothalamic hamartoma"],"prefix":"10.1111","volume":"58","author":[{"given":"J.","family":"Helen Cross","sequence":"first","affiliation":[{"name":"UCL\u2010Institute of Child Health Great Ormond Street Hospital for Children London United Kingdom"},{"name":"Young Epilepsy Lingfield United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Spoudeas","sequence":"additional","affiliation":[{"name":"Great Ormond Street Hospital for Children &amp; University College Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-5050(03)00086-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1525-5050(03)00086-6"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr235"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.spen.2007.03.003"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320070110"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0397-266"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.05.031"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1684\/j.1950-6945.2003.tb00012.x","article-title":"Hypothalamic hamartoma and epilepsy in children: illustrative cases of possible evolutions","volume":"5","author":"Arzimanoglou A","year":"2003","journal-title":"Epileptic Dis"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2012.09.013"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-014-0374-z"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(95)00063-5"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01455.x"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02942.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000049457.05670.7D"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(08)70092-9"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0012"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2011.02.004"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13758","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T16:45:39Z","timestamp":1719247539000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":17,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/epi.13758"],"URL":"https:\/\/doi.org\/10.1111\/epi.13758","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}