{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T05:57:42Z","timestamp":1792648662119,"version":"4.5.0"},"reference-count":22,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Gamma Knife radiosurgery (GK) is an effective treatment for hypothalamic hamartoma. No precise data are available on the risk of endocrine side effects of this treatment. In this study, 34 patients with hypothalamic hamartoma (HH) were followed prospectively at the Department of Endocrinology, La Timone Hospital, Marseille, France, for a mean follow\u2010up of &gt;2\u00a0years (mean \u00b1 standard deviation [SD] 3.6\u00a0\u00b1\u00a02\u00a0years). Initial pre\u2010 and post\u2010GK radiosurgery evaluations were performed, including weight, body mass index (BMI), and a complete endocrinological workup. At diagnosis, eight patients presented with central precocious puberty at a mean age of 5.4\u00a0\u00b1\u00a02.4\u00a0years. At the time of GK (mean age 18.2\u00a0\u00b1\u00a011.1\u00a0years), two patients previously treated with surgery presented with luteinizing hormone\/follicle\u2010stimulating hormone (LH\/FSH) deficiency. After GK, only one patient presented with a new thyrotropin\u2010stimulating hormone (TSH) deficiency, 2\u00a0years after the procedure. The other pituitary axes remained normal in all but two patients (who had LH\/FSH deficiency prior to GK). There was no significant difference between pre\u2010 and post\u2010GK mean BMI (26.9 vs. 25.1\u00a0kg\/m<jats:sup>2<\/jats:sup>, p\u00a0=\u00a00.59). To conclude, in this group of 34 patients, GK did not induce major endocrinologic side effects reported with all the other surgical techniques in the literature. It is, thus, a safe and effective procedure in the treatment of hypothalamic hamartoma.<\/jats:p>","DOI":"10.1111\/epi.13760","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T20:35:26Z","timestamp":1496867726000},"page":"72-76","source":"Crossref","is-referenced-by-count":26,"title":["Gamma Knife radiosurgery for hypothalamic hamartoma preserves endocrine functions"],"prefix":"10.1111","volume":"58","author":[{"given":"Frederic","family":"Castinetti","sequence":"first","affiliation":[{"name":"Department of Endocrinology Assistance Publique H\u00f4pitaux de Marseille La Timone Hospital Aix\u2010Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Brue","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Assistance Publique H\u00f4pitaux de Marseille La Timone Hospital Aix\u2010Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Morange","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Assistance Publique H\u00f4pitaux de Marseille La Timone Hospital Aix\u2010Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Carron","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Assistance Publique H\u00f4pitaux de Marseille La Timone Hospital Aix\u2010Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"R\u00e9gis","sequence":"additional","affiliation":[{"name":"Department of Functional Neurosurgery Assistance Publique H\u00f4pitaux de Marseille La Timone Hospital Aix\u2010Marseille University Marseille France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.3.FOCUS1355"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.62"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-022018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000308162"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1542\/peds.67.2.236","article-title":"Precocious puberty and hypothalamic hamartoma","volume":"67","author":"Hochman HI","year":"1981","journal-title":"Pediatrics"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.2.546"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.05.014"},{"key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1684\/j.1950-6945.2003.tb00018.x","article-title":"The endocrinology of hypothalamic hamartoma surgery for intractable epilepsy","volume":"5","author":"Freeman JL","year":"2003","journal-title":"Epileptic Disord"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/JPEM.2001.14.2.141"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2013-0108"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000318279.92233.82"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3171\/2012.5.JNS112256"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-0583-2_4"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2003.11.021"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.8.GKS141608"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000364915"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-006-0139-y"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/neurosurgery\/47.6.1343"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3171\/2010.8.GKS101027"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2010.4"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.4.PEDS12617"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.80.3.231"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T16:45:33Z","timestamp":1719247533000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":22,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/epi.13760"],"URL":"https:\/\/doi.org\/10.1111\/epi.13760","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6]]}}}