{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:49:34Z","timestamp":1791265774722,"version":"4.1.0"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T00:00:00Z","timestamp":1493683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Seizure spread into autonomic and respiratory brainstem regions is thought to play an important role in sudden unexpected death in epilepsy (<jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>). As the clinical dataset of cases of definite <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> available for study grows, evidence points to a sequence of events that includes postictal apnea, bradycardia, and asystole as critical events that can lead to death. One possible link between the precipitating seizure and the critical postictal sequence is seizure\u2010driven laryngospasm sufficient to completely obstruct the airway for an extended period, but ictal laryngospasm is difficult to fully assess. Herein, we demonstrate in a rat model how the electrical artifacts of attempts to inspire during airway obstruction and features of the cardiac rhythm establish this link between ictal and postictal activity and can be used as practical biomarkers of obstructive apnea due to laryngospasm or other causes of airway obstruction.<\/jats:p>","DOI":"10.1111\/epi.13765","type":"journal-article","created":{"date-parts":[[2017,5,2]],"date-time":"2017-05-02T17:38:46Z","timestamp":1493746726000},"source":"Crossref","is-referenced-by-count":53,"title":["Obstructive apnea due to laryngospasm links ictal to postictal events in <scp>SUDEP<\/scp> cases and offers practical biomarkers for review of past cases and prevention of new ones"],"prefix":"10.1111","volume":"58","author":[{"given":"Mark","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Neurology SUNY Downstate Medical Center Brooklyn New York U.S.A."},{"name":"Department of Physiology\/Pharmacology SUNY Downstate Medical Center Brooklyn New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Kollmar","sequence":"additional","affiliation":[{"name":"Department of Cell Biology SUNY Downstate Medical Center Brooklyn New York U.S.A."},{"name":"Department of Otolaryngology SUNY Downstate Medical Center Brooklyn New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Nakase","sequence":"additional","affiliation":[{"name":"Department of Physiology\/Pharmacology SUNY Downstate Medical Center Brooklyn New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology SUNY Downstate Medical Center Brooklyn New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishnamurthi","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology SUNY Downstate Medical Center Brooklyn New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena","family":"Orman","sequence":"additional","affiliation":[{"name":"Department of Physiology\/Pharmacology SUNY Downstate Medical Center Brooklyn New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Lazar","sequence":"additional","affiliation":[{"name":"Department of Medicine SUNY Downstate Medical Center Brooklyn New York U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70214-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30158-2"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3181b7f14d"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2350\/08-06-0485.1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01781.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.2.151"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2016.08.004"},{"key":"e_1_2_6_9_1","first-page":"627","volume-title":"Sudden death in epilepsy: forensic and clinical issues","author":"Stewart M","year":"2011"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2008.01860.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.13765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.13765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T05:29:00Z","timestamp":1696224540000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.13765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,2]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/epi.13765"],"URL":"https:\/\/doi.org\/10.1111\/epi.13765","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,2]]}}}