{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T20:34:57Z","timestamp":1793738097395,"version":"4.6.1"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T00:00:00Z","timestamp":1494201600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001782","name":"University of Melbourne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001782","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Summary<\/jats:title>Objective<\/jats:title>To evaluate factors predicting efficacy, retention, and tolerability of add\u2010on brivaracetam (BRV<\/jats:styled-content>) in clinical practice.<\/jats:p><\/jats:sec>Methods<\/jats:title>A multicenter, retrospective cohort study recruiting all patients who started BRV<\/jats:styled-content> between February and November 2016 with observation time between 3 and 12 months.<\/jats:p><\/jats:sec>Results<\/jats:title>Of a total of 262 patients (mean age 40, range 5\u201381 years, 129 male) treated with BRV<\/jats:styled-content>, 227 (87%) were diagnosed to have focal, 19 (7%) idiopathic generalized and 8 (3%) symptomatic generalized epilepsy, whereas 8 (3%) were unclassified. The length of exposure to BRV<\/jats:styled-content> ranged from 1 day to 12 months, with a median retention time of 6.1 months, resulting in a total exposure time to BRV<\/jats:styled-content> of 1,504 months. The retention rate was 79.4% at 3 months and 75.8% at 6 months. Efficacy at 3 months was 41.2% (50% responder rate) with 14.9% seizure\u2010free for 3 months and, at 6 months, 40.5% with 15.3% seizure\u2010free. Treatment\u2010emergent adverse events were observed in 37.8% of the patients, with the most common being somnolence, dizziness, and behavioral adverse events (BAEs<\/jats:styled-content>). BAE<\/jats:styled-content> that presented under previous levetiracetam (LEV<\/jats:styled-content>) treatment improved upon switch to BRV<\/jats:styled-content> in 57.1% (20\/35) and LEV<\/jats:styled-content>\u2010induced somnolence improved in 70.8% (17\/24). Patients with BAE<\/jats:styled-content> on LEV<\/jats:styled-content> were more likely to develop BAE<\/jats:styled-content> on BRV<\/jats:styled-content> (odds ratio [OR<\/jats:styled-content>] 3.48, 95% confidence interval [CI<\/jats:styled-content>] 1.53\u20137.95).<\/jats:p><\/jats:sec>Significance<\/jats:title>BRV<\/jats:styled-content> in broad clinical postmarketing use is a well\u2010tolerated anticonvulsant drug with 50% responder rates, similar to those observed in the regulatory trials, even though 90% of the patients included had previously been exposed to LEV<\/jats:styled-content>. An immediate switch from LEV<\/jats:styled-content> to BRV<\/jats:styled-content> at a ratio of 10:1 to 15:1 is feasible. The only independent significant predictor of efficacy was the start of BRV<\/jats:styled-content> in patients not currently taking LEV<\/jats:styled-content>. The occurrence of BAE<\/jats:styled-content> during previous LEV<\/jats:styled-content> exposure predicted poor psychobehavioral tolerability of BRV<\/jats:styled-content> treatment. A switch to BRV<\/jats:styled-content> can be considered in patients with LEV<\/jats:styled-content>\u2010induced BAE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13768","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T06:49:46Z","timestamp":1494226186000},"page":"1208-1216","source":"Crossref","is-referenced-by-count":106,"title":["Postmarketing experience with brivaracetam in the treatment of epilepsies: A multicenter cohort study from Germany"],"prefix":"10.1111","volume":"58","author":[{"given":"Isabel","family":"Steinig","sequence":"first","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe\u2010University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felix","family":"von Podewils","sequence":"additional","affiliation":[{"name":"Epilepsy Center Greifswald and Department of Neurology Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"M\u00f6ddel","sequence":"additional","affiliation":[{"name":"Department of Sleep Medicine and Neuromuscular Disorders Epilepsy Center M\u00fcnster\u2010Osnabr\u00fcck Westf\u00e4lische Wilhelms\u2010University M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bauer","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe\u2010University Frankfurt am Main Germany"},{"name":"Epilepsy Center Hessen and Department of Neurology Philipps\u2010University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl Martin","family":"Klein","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe\u2010University Frankfurt am Main Germany"},{"name":"Epilepsy Center Hessen and Department of Neurology Philipps\u2010University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Paule","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe\u2010University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp S.","family":"Reif","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe\u2010University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent M.","family":"Willems","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe\u2010University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann Philipp","family":"Z\u00f6llner","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main and Department of Neurology Goethe\u2010University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhina","family":"Kunz","sequence":"additional","affiliation":[{"name":"Epilepsy Center Greifswald and Department of Neurology Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Runge","sequence":"additional","affiliation":[{"name":"Epilepsy Center Greifswald and Department of Neurology Ernst\u2010Moritz\u2010Arndt\u2010University Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kurlemann","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics Westf\u00e4lische Wilhelms\u2010University M\u00fcnster 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