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This review focuses on the association of epilepsy with autism spectrum disorder (ASD) and depression. There is high concordance of these behavioral pathologies with epilepsy. We review data that unambiguously reveal that epilepsy, ASD, and depression are associated with elevated brain inflammatory markers and that these may interact with serotoninergic pathways. Interference with inflammatory pathways or actions can reduce the severity of seizures, depression, and ASD\u2010like behavior. Inflammation in the brain can be induced by seizure activity as well as by behavioral, environmental, and physiologic stressors. Furthermore, induction of inflammation at an early time point during gestation and in early neonatal life can precipitate both an ASD\u2010like phenotype as well as a more excitable brain. It appears likely that priming of the brain due to early inflammation could provide a means by which subsequent inflammatory processes associated with epilepsy, ASD, and depression may lead to comorbidity.<\/jats:p>","DOI":"10.1111\/epi.13786","type":"journal-article","created":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T15:13:10Z","timestamp":1499181190000},"page":"48-56","source":"Crossref","is-referenced-by-count":89,"title":["Neurobehavioral comorbidities of epilepsy: Role of inflammation"],"prefix":"10.1111","volume":"58","author":[{"given":"Andrey M.","family":"Mazarati","sequence":"first","affiliation":[{"name":"Neurology Division Department of Pediatrics David Geffen School of Medicine University of California Los Angeles Los Angeles California U.S.A"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan L.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Physiology &amp; Pharmacology Hotchkiss Brain Institute University of 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