{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T13:59:53Z","timestamp":1787061593838,"version":"build-2736575974"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["279062"],"award-info":[{"award-number":["279062"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000836","name":"University of Liverpool","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007870","name":"Deutsche Gesellschaft f\u00fcr Epileptologie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,10]]},"abstract":"Summary<\/jats:title>\n \n Objective<\/jats:title>\n \n Mesial temporal lobe epilepsy with hippocampal sclerosis (\n MTLE<\/jats:styled-content>\n \u2010\n HS<\/jats:styled-content>\n ) is a common epilepsy syndrome that is often poorly controlled by antiepileptic drug (\n AED<\/jats:styled-content>\n ) treatment. Comparative\n AED<\/jats:styled-content>\n effectiveness studies in this condition are lacking. We report retention, efficacy, and tolerability in a cohort of patients with\n MTLE<\/jats:styled-content>\n \u2010\n HS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Clinical data were collected from a European database of patients with epilepsy. We estimated retention, 12\u2010month seizure freedom, and adverse drug reaction (\n ADR<\/jats:styled-content>\n ) rates for the 10 most commonly used\n AED<\/jats:styled-content>\n s in patients with\n MTLE<\/jats:styled-content>\n \u2010\n HS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Seven hundred sixty\u2010seven patients with a total of 3,249\n AED<\/jats:styled-content>\n trials were included. The highest 12\u2010month retention rates were observed with carbamazepine (85.9%), valproate (85%), and clobazam (79%). Twelve\u2010month seizure freedom rates varied from 1.2% for gabapentin and vigabatrin to 11% for carbamazepine. Response rates were highest for\n AED<\/jats:styled-content>\n s that were prescribed as initial treatment and lowest for\n AED<\/jats:styled-content>\n s that were used in a third or higher instance.\n ADR<\/jats:styled-content>\n s were reported in 47.6% of patients, with the highest rates observed with oxcarbazepine (35.7%), topiramate (30.9%), and pregabalin (27.4%), and the lowest rates with clobazam (6.5%), gabapentin (8.9%), and lamotrigine (16.6%). The most commonly reported\n ADR<\/jats:styled-content>\n s were lethargy and drowsiness, dizziness, vertigo and ataxia, and blurred vision and diplopia.\n <\/jats:p>\n <\/jats:sec>\n \n Significance<\/jats:title>\n \n Our results did not demonstrate any clear advantage of newer versus older\n AED<\/jats:styled-content>\n s. Our results provide useful insights into\n AED<\/jats:styled-content>\n retention, efficacy, and\n ADR<\/jats:styled-content>\n rates in patients with\n MTLE<\/jats:styled-content>\n \u2010\n HS<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/epi.13871","type":"journal-article","created":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T08:09:19Z","timestamp":1504166959000},"page":"1734-1741","source":"Crossref","is-referenced-by-count":34,"title":["Comparative effectiveness of antiepileptic drugs in patients with mesial temporal lobe epilepsy with hippocampal sclerosis"],"prefix":"10.1111","volume":"58","author":[{"given":"Ganna","family":"Androsova","sequence":"first","affiliation":[{"name":"Luxembourg Center for Systems Biomedicine University of Luxembourg Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Krause","sequence":"additional","affiliation":[{"name":"Luxembourg Center for Systems Biomedicine University of Luxembourg Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgansadat","family":"Borghei","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Neurology Universit\u00e9 Libre de Bruxelles Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merel","family":"Wassenaar","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauls","family":"Auce","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool United Kingdom"},{"name":"The Walton Centre NHS Foundation Trust Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1352-5127","authenticated-orcid":false,"given":"Andreja","family":"Avbersek","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy UCL Institute of Neurology London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felicitas","family":"Becker","sequence":"additional","affiliation":[{"name":"Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca","family":"Berghuis","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Campbell","sequence":"additional","affiliation":[{"name":"Belfast Health and Social Care Trust Belfast United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Coppola","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Muscular Diseases Unit Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Francis","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Liverpool Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Wolking","sequence":"additional","affiliation":[{"name":"Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianpiero L.","family":"Cavalleri","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Craig","sequence":"additional","affiliation":[{"name":"Belfast Health and Social Care Trust Belfast United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman","family":"Delanty","sequence":"additional","affiliation":[{"name":"Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland"},{"name":"Department of Neurology Beaumont Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bobby P. C.","family":"Koeleman","sequence":"additional","affiliation":[{"name":"Department of Genetics University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram S.","family":"Kunz","sequence":"additional","affiliation":[{"name":"Department of Epileptology University of Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Lerche","sequence":"additional","affiliation":[{"name":"Hertie Institute for Clinical Brain Research University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony G.","family":"Marson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool United Kingdom"},{"name":"The Walton Centre NHS Foundation Trust Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6041-9661","authenticated-orcid":false,"given":"Josemir W.","family":"Sander","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN) Heemstede The Netherlands"},{"name":"NIHR University College London Hospitals Biomedical Research Centre UCL Institute of Neurology London United Kingdom"},{"name":"The Chalfont Centre for Epilepsy Chalfont St. Peters United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graeme J.","family":"Sills","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Pharmacology Institute of Translational Medicine University of Liverpool Liverpool United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-1476","authenticated-orcid":false,"given":"Pasquale","family":"Striano","sequence":"additional","affiliation":[{"name":"Pediatric Neurology and Muscular Diseases Unit Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health University of Genoa Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Zara","sequence":"additional","affiliation":[{"name":"Laboratory of Neurogenetics and Neuroscience Institute G. 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