{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:39:51Z","timestamp":1775003991026,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T00:00:00Z","timestamp":1503964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","award":["D43 TW001140"],"award-info":[{"award-number":["D43 TW001140"]}],"id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Using a large\u2010scale population\u2010based study, we aimed to assess prevalence and patterns of presentation of neurocysticercosis (<jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>) and its relationship with epilepsy in community\u2010dwellers aged \u226520\u00a0years living in Atahualpa (rural Ecuador).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a three\u2010phase epidemiological study, individuals with suspected seizures were identified during a door\u2010to\u2010door survey and an interview (phase I). Then, neurologists evaluated suspected cases and randomly selected negative persons to estimate epilepsy prevalence (phase II). In phase III, all participants were offered noncontrast computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) for identifying <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content> cases. The independent association between <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content> (exposure) and epilepsy (outcome) was assessed by the use of multivariate logistic regression models adjusted for age, sex, level of education, and alcohol intake. <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> findings were subsequently compared to archived brain magnetic resonance imaging in a sizable subgroup of participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1,604 villagers aged \u226520\u00a0years, 1,462 (91%) were enrolled. Forty\u2010one persons with epilepsy (<jats:styled-content style=\"fixed-case\">PWE<\/jats:styled-content>) were identified, for a crude prevalence of epilepsy of 28 per 1,000 population (95% confidence interval [CI] = 20.7\u201338.2). A head <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> was performed in 1,228 (84%) of 1,462 participants, including 39 of 41 <jats:styled-content style=\"fixed-case\">PWE<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> showed lesions consistent with calcified parenchymal brain cysticerci in 118 (9.6%) cases (95% CI = 8.1\u201311.4%). No patient had other forms of <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content>. Nine of 39 <jats:styled-content style=\"fixed-case\">PWE<\/jats:styled-content>, as opposed to 109 of 1,189 participants without epilepsy, had <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content> (23.1% vs. 9.2%, p\u00a0=\u00a00.004). This difference persisted in the adjusted logistic regression model (odds ratio = 3.04, 95% CI = 1.35\u20136.81, p\u00a0=\u00a00.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>This large <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u2010based study demonstrates that <jats:styled-content style=\"fixed-case\">PWE<\/jats:styled-content> had three times the odds of having <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content> than those without epilepsy, providing robust epidemiological evidence favoring the relationship between <jats:styled-content style=\"fixed-case\">NCC<\/jats:styled-content> and epilepsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13892","type":"journal-article","created":{"date-parts":[[2017,8,29]],"date-time":"2017-08-29T15:08:48Z","timestamp":1504019328000},"page":"1955-1961","source":"Crossref","is-referenced-by-count":46,"title":["On the relationship between calcified neurocysticercosis and 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