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However, recent studies raise contradictory evidence with increasing use of quantitative magnetic resonance imaging techniques. Following<jats:styled-content style=\"fixed-case\">PRISMA<\/jats:styled-content>guidelines, a systematic, quantitative review was conducted using 28 peer\u2010reviewed, case\u2013control studies published after 1989. Furthermore, a meta\u2010analysis with a random\u2010effect model revealed differences in structural brain abnormalities between<jats:styled-content style=\"fixed-case\">GGE<\/jats:styled-content>patients and controls. Significant structural differences between<jats:styled-content style=\"fixed-case\">GGE<\/jats:styled-content>and healthy controls were observed with volume reductions in whole brain, thalamus, putamen, caudate, pallidum, and supplementary motor area. Furthermore, gray matter volume reduction in the right and left hemispheres, thalamus, and insula, and surface area reduction in the caudal anterior cingulate cortex were revealed, along with gray matter increase in the medial frontal gyrus. Due to methodological differences, findings should be interpreted with caution. Nevertheless, contrary to the<jats:styled-content style=\"fixed-case\">ILAE<\/jats:styled-content>definition, it would appear that structural brain abnormalities may be present in<jats:styled-content style=\"fixed-case\">GGE<\/jats:styled-content>patients. Findings are consistent with a hypothesis regarding the underlying involvement of the thalamocortical networks in the generation of generalized spike\u2010wave discharges, but structural abnormalities appear to extend outside these regions to potentially involve attention and other cognitive domains.<\/jats:p>","DOI":"10.1111\/epi.13928","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T06:46:34Z","timestamp":1508827594000},"page":"2025-2037","source":"Crossref","is-referenced-by-count":48,"title":["Structural brain abnormalities in genetic generalized epilepsies: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"58","author":[{"given":"Shauni","family":"Nuyts","sequence":"first","affiliation":[{"name":"Department of Psychological Sciences University of Leuven Leuven Belgium"},{"name":"Department of Statistics University of Leuven Leuven Belgium"},{"name":"Melbourne School of Psychological Sciences University of Melbourne 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