{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:12:39Z","timestamp":1783537959608,"version":"3.55.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Schmidlapp's Women's Scholar Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine baseline psychological functioning and antiepileptic drug (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>) behavioral side effects in new onset epilepsy and determine, by age, whether baseline psychological functioning predicts <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> behavioral side effects 1\u00a0month following <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> initiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was conducted between July 2011 and December 2014 that included youths with new onset epilepsy. As part of routine interdisciplinary care, caregivers completed the Behavior Assessment System for Children, 2nd Edition: Parent Rating Scale to report on baseline psychological functioning at the diagnostic visit and the Pediatric Epilepsy Side Effects Questionnaire to identify <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> behavioral side effects at the 1\u2010month follow\u2010up clinic visit following <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> initiation. Children (age = 2\u201011\u00a0years) and adolescents (age = 12\u201018\u00a0years) were examined separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 380 youths with new onset epilepsy (<jats:italic>M<\/jats:italic><jats:sub><jats:italic>age<\/jats:italic><\/jats:sub>\u00a0=\u00a08.9\u00a0\u00b1\u00a04.3\u00a0years; 83.4% Caucasian; 34.8% focal epilepsy, 41.1% generalized epilepsy, 23.7% unclassified epilepsy) were included. Seventy percent of youths had at\u2010risk or clinically elevated baseline psychological symptoms. Children had significantly greater <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> behavioral side effects (<jats:italic>M\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>25.08\u00a0\u00b1\u00a026.36) compared to adolescents (<jats:italic>M\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>12.36\u00a0\u00b1\u00a017.73), regardless of <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>. Valproic acid demonstrated significantly greater behavioral side effects compared to all other <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s, with the exception of levetiracetam. Higher hyperactivity\/impulsivity at baseline significantly predicted higher <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> behavioral side effects 1\u00a0month after <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> initiation in both age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Younger children seem to be more prone to experience behavioral side effects, and these are likely to be higher if youths with epilepsy have baseline hyperactivity\/impulsivity. Baseline psychological screening, specifically hyperactivity, can be used as a precision medicine tool for <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> selection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.13946","type":"journal-article","created":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T09:11:44Z","timestamp":1510132304000},"page":"146-154","source":"Crossref","is-referenced-by-count":29,"title":["Antiepileptic drug behavioral side effects and baseline hyperactivity in children and adolescents with new onset epilepsy"],"prefix":"10.1111","volume":"59","author":[{"given":"Shanna M.","family":"Guilfoyle","sequence":"first","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Center for the Promotion of Adherence and Self\u2010Management Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Follansbee\u2010Junger","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Center for the Promotion of Adherence and Self\u2010Management Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aimee W.","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Center for the Promotion of Adherence and Self\u2010Management Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Combs","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Center for the Promotion of Adherence and Self\u2010Management Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Ollier","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Center for the Promotion of Adherence and Self\u2010Management Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Hater","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Center for the Promotion of Adherence and Self\u2010Management Cincinnati Children's Hospital Medical Center Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avani C.","family":"Modi","sequence":"additional","affiliation":[{"name":"Division of Behavioral Medicine and Clinical Psychology Center for the Promotion of Adherence and Self\u2010Management Cincinnati Children's Hospital Medical Center Cincinnati OH USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine Cincinnati OH 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