{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T07:09:33Z","timestamp":1792480173697,"version":"4.5.0"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T00:00:00Z","timestamp":1517529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["FDM20150632965"],"award-info":[{"award-number":["FDM20150632965"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Oroalimentary automatisms (\n                      <jats:styled-content style=\"fixed-case\">OAA<\/jats:styled-content>\n                      s) resembling normal alimentary behavior are stereotyped complex movements that may occur during epileptic seizures. They are considered common clinical signs in temporal lobe seizures, but their anatomofunctional mechanisms are not established. We took the opportunity of presurgical intracerebral recordings to study the relations between the occurrence of\n                      <jats:styled-content style=\"fixed-case\">OAA<\/jats:styled-content>\n                      s and temporal\/spatial features of ictal activities.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively reviewed patients with medically intractable medial temporal lobe epilepsy who underwent stereoelectroencephalography (\n                      <jats:styled-content style=\"fixed-case\">SEEG<\/jats:styled-content>\n                      ) at Cleveland Clinic between 2009 and 2016. Patients presenting oroalimentary automatisms during seizures, with intracerebral electrodes spanning temporal and extratemporal areas, were selected.\n                      <jats:styled-content style=\"fixed-case\">SEEG<\/jats:styled-content>\n                      \u2010clinical correlations with latency measurements were done. Coherence analyses were performed on regions of interest as defined by the areas involved at the onset of oroalimentary automatisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Fifteen patients (115 seizures) were analyzed. Sixty\u2010nine seizures exhibited overt oroalimentary automatisms. Only insulo\u2010opercular cortex ictal involvement was consistently related to the occurrence of\n                      <jats:styled-content style=\"fixed-case\">OAA<\/jats:styled-content>\n                      s, with a linear correlation between\n                      <jats:styled-content style=\"fixed-case\">OAA<\/jats:styled-content>\n                      onset and ictal oscillatory activity onset in the insulo\u2010opercular cortex.\n                      <jats:styled-content style=\"fixed-case\">SEEG<\/jats:styled-content>\n                      signal processing showed an increase in theta coherence preceding oroalimentary automatism onset between mediobasal\u2010temporal structures and insulo\u2010opercular cortex, as well as between the 2 insulo\u2010opercular regions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Significance<\/jats:title>\n                    <jats:p>The underlying mechanism for the production of oroalimentary automatisms in medial temporal seizures is based on temporal\u2010insulo\u2010opercular theta coherence leading to a synchronous state generating rhythmic patterned outputs from the cortical masticatory area.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/epi.14011","type":"journal-article","created":{"date-parts":[[2018,2,2]],"date-time":"2018-02-02T02:12:42Z","timestamp":1517537562000},"page":"583-594","source":"Crossref","is-referenced-by-count":46,"title":["Insulo\u2010opercular cortex generates oroalimentary automatisms in temporal seizures"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7268-7479","authenticated-orcid":false,"given":"Jerome","family":"Aupy","sequence":"first","affiliation":[{"name":"Epilepsy Center Cleveland Clinic Neurological Institute Cleveland OH USA"},{"name":"Department of Clinical Neurosciences Bordeaux University Hospital Bordeaux France"},{"name":"University of Bordeaux Institute of Neurodegenerative Diseases National Center for Scientific Research Mixed Unit of Research 5293 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ika","family":"Noviawaty","sequence":"additional","affiliation":[{"name":"Epilepsy Center Cleveland Clinic Neurological Institute Cleveland OH USA"},{"name":"Department of Neurology University of Massachusetts Medical School Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Balu","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Epilepsy Center Cleveland Clinic Neurological Institute Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piradee","family":"Suwankpakdee","sequence":"additional","affiliation":[{"name":"Epilepsy Center Cleveland Clinic Neurological Institute Cleveland OH USA"},{"name":"Pediatric Neurology Phramongkutklao Hospital Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bulacio","sequence":"additional","affiliation":[{"name":"Epilepsy Center Cleveland Clinic Neurological Institute Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Gonzalez\u2010Martinez","sequence":"additional","affiliation":[{"name":"Epilepsy Center Cleveland Clinic Neurological Institute Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imad","family":"Najm","sequence":"additional","affiliation":[{"name":"Epilepsy Center Cleveland Clinic Neurological Institute Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Chauvel","sequence":"additional","affiliation":[{"name":"Epilepsy Center Cleveland Clinic Neurological Institute Cleveland OH 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