{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:09:58Z","timestamp":1760299798904},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T00:00:00Z","timestamp":1517356800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"Summary<\/jats:title>The objective of our study was to assess alterations in speech as a possible localizing sign in frontal lobe epilepsy. Ictal speech was analyzed in 18 patients with frontal lobe epilepsy (FLE<\/jats:styled-content>) during seizures and in the interictal period. Matched identical words were analyzed regarding alterations in fundamental frequency (\u0192o) as an approximation of pitch. In patients with FLE<\/jats:styled-content>, \u0192o of ictal utterances was significantly higher than \u0192o in interictal recordings (p = 0.016). Ictal \u0192o increases occurred in both FLE<\/jats:styled-content> of right and left seizure origin. In contrast, a matched temporal lobe epilepsy (TLE<\/jats:styled-content>) group showed less pronounced increases in \u0192o, and only in patients with right\u2010sided seizure foci. This study for the first time shows significant voice alterations in ictal speech in a cohort of patients with FLE<\/jats:styled-content>. This may contribute to the localization of the epileptic focus. Increases in \u0192o were interestingly found in frontal lobe seizures with origin in either hemisphere, suggesting a bilateral involvement to the planning of speech production, in contrast to a more right\u2010sided lateralization of pitch perception in prosodic processing.<\/jats:p>","DOI":"10.1111\/epi.14012","type":"journal-article","created":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T04:32:40Z","timestamp":1517459560000},"source":"Crossref","is-referenced-by-count":7,"title":["Frontal lobe epileptic seizures are accompanied by elevated pitch during verbal communication"],"prefix":"10.1111","volume":"59","author":[{"given":"Iva","family":"Speck","sequence":"first","affiliation":[{"name":"Epilepsy Center Department Presurgical Diagnostics Faculty of Medicine Medical Center\u2014University of Freiburg University of Freiburg Freiburg Germany"},{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Faculty of Medicine Medical Center\u2014University of Freiburg University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Echternach","sequence":"additional","affiliation":[{"name":"Freiburg Institute of Musicians\u2019 Medicine Faculty of Medicine (FIM) Faculty of Medicine Medical Center\u2010 University of Freiburg University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Sammler","sequence":"additional","affiliation":[{"name":"Otto Hahn Group \u201cNeural Bases of Intonation in Speech and Music\u201d Max Planck Institute for Human Cognitive and Brain Sciences Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Schulze\u2010Bonhage","sequence":"additional","affiliation":[{"name":"Epilepsy Center Department Presurgical Diagnostics Faculty of Medicine Medical Center\u2014University of Freiburg University of Freiburg Freiburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/02687039508248709"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318232abae"},{"key":"e_1_2_8_4_1","unstructured":"BoersmaP WeeninkD.Praat: doing phonetics by computer 2015. 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