{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:34:00Z","timestamp":1787938440730,"version":"build-2784847793"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006117","name":"Epilepsiefonds","doi-asserted-by":"publisher","award":["WAR 08\u201010"],"award-info":[{"award-number":["WAR 08\u201010"]}],"id":[{"id":"10.13039\/501100006117","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The objective of this study was to create a clinically useful tool for individualized prediction of seizure outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery. We used data from the European retrospective <jats:italic>TimeToStop<\/jats:italic> study, which included 766 children from 15 centers, to perform a proportional hazard regression analysis. The 2 outcome measures were seizure recurrence and seizure freedom in the last year of follow\u2010up. Prognostic factors were identified through systematic review of the literature. The strongest predictors for each outcome were selected through backward selection, after which nomograms were created. The final models included 3 to 5 factors per model. Discrimination in terms of adjusted concordance statistic was 0.68 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 0.67\u20100.69) for predicting seizure recurrence and 0.73 (95%<jats:styled-content style=\"fixed-case\"> CI<\/jats:styled-content> 0.72\u20100.75) for predicting eventual seizure freedom. An online prediction tool is provided on <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.epilepsypredictiontools.info\/ttswithdrawal\">www.epilepsypredictiontools.info\/ttswithdrawal<\/jats:ext-link>. The presented models can improve counseling of patients and parents regarding postoperative <jats:styled-content style=\"fixed-case\">antiepileptic drug<\/jats:styled-content> policies, by estimating individualized risks of seizure recurrence and eventual outcome.<\/jats:p>","DOI":"10.1111\/epi.14020","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T11:26:57Z","timestamp":1518694017000},"source":"Crossref","is-referenced-by-count":32,"title":["Individualized prediction of seizure relapse and outcomes following antiepileptic drug withdrawal after pediatric epilepsy surgery"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1379-3487","authenticated-orcid":false,"given":"Herm J.","family":"Lamberink","sequence":"first","affiliation":[{"name":"Department of Child Neurology Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Boshuisen","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1511-6834","authenticated-orcid":false,"given":"Willem M.","family":"Otte","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Biomedical MR Imaging and Spectroscopy Group Center for Image Sciences University Medical Center Utrecht Utrecht The Netherlands"},{"name":"Stichting Epilepsie Instellingen Nederland\u2013SEIN Heemstede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Geleijns","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kees P. J.","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Brain Center Rudolf Magnus University Medical Center Utrecht Utrecht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the TimeToStop Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821527f0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2013.08.004"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24427"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.02.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2007.05.014"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70165-5"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21884"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182644f7d"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.35"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2006.00371.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30114-X"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2015.0764"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.14020","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.14020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T07:09:01Z","timestamp":1695625741000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.14020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1111\/epi.14020"],"URL":"https:\/\/doi.org\/10.1111\/epi.14020","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]}}}