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Non\u2013electroencephalography (EEG) seizure detection systems using mobile sensor devices permit caregivers to assist patients during seizures and may reduce risks for complications of seizures such as injuries and <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>. We review changes in accelerometry, electrodermal activity, and heart rate associated with tonic\u2013clonic seizures and their use in detection systems, including multimodal detectors. We reviewed current and past publications reporting data on linkage between <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content>, post\u2010ictal generalized <jats:styled-content style=\"fixed-case\">EEG<\/jats:styled-content> suppression (<jats:styled-content style=\"fixed-case\">PGES<\/jats:styled-content>), and ventilatory dysfunction. The timing and duration of postictal immobility and respiratory dysfunction associated with convulsions help identify which patients might benefit the most from seizure monitoring and from benchmarks for the timing of seizure detection, caregiver alerting, and interventions.<\/jats:p>","DOI":"10.1111\/epi.14046","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T14:24:53Z","timestamp":1528295093000},"page":"36-41","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Strategies for non\u2010<scp>EEG<\/scp> seizure detection and timing for alerting and interventions with tonic\u2013clonic seizures"],"prefix":"10.1111","volume":"59","author":[{"given":"Erie G.","family":"Gutierrez","sequence":"first","affiliation":[{"name":"Department of Neurology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan E.","family":"Crone","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joon Y.","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaretson I.","family":"Carmenate","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory L.","family":"Krauss","sequence":"additional","affiliation":[{"name":"Department of Neurology Johns Hopkins University Baltimore MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003685"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30158-2"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13897"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13083"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.06.014"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2005.04.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e3182051320"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.01.019"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2013.2244597"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1109\/JBHI.2013.2285015"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03444.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","unstructured":"ConradsenI BeniczkyS WolfP et\u00a0al.Seizure onset detection based on a Uni\u2010 or Multi\u2010modal Intelligent Seizure Acquisition (UISA\/MISA) system. 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