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The recent development in such devices and their performance offer multiple opportunities to tackle <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> and its prevention. Reliable <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content> detection might help physicians optimize antiepileptic treatment, which could in turn reduce the risk of <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>. <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content>\u2010triggered alarms can lead to immediate intervention by caregivers that are also likely to decrease the odd of <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>. The biosignals used to detect <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content> might provide novel <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> biomarkers, in particular, by informing on several important characteristics of the ictal and postictal periods (type of <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content>, duration of tonic phase, rotation in the prone position, presence and duration of postictal immobility and bradycardia, rise in electrodermal activity). Other biosensors not yet used for detecting <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content> might provide complementary information, such as the presence and intensity of ictal\/postictal hypoxemia. The above biomarkers, if strongly predictive, could help identify patients at very high risk of <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>, enabling better assessment of individual risk, as well as selection of appropriate patients for clinical studies aiming at preventing <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>. The same biosignals could also be used as ancillary biomarkers to test the impact of various interventions before moving to highly challenging randomized controlled trials with <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> as a primary outcome.<\/jats:p>","DOI":"10.1111\/epi.14054","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T14:24:53Z","timestamp":1528295093000},"page":"61-66","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Wearable devices for sudden unexpected death in epilepsy prevention"],"prefix":"10.1111","volume":"59","author":[{"given":"Philippe","family":"Ryvlin","sequence":"first","affiliation":[{"name":"Department of Clinical Neurosciences CHUV Lausanne Switzerland"},{"name":"Epilepsy Institute (IDEE) Lyon 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