{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:29:08Z","timestamp":1761060548739},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Summary<\/jats:title>Arterial spin labeling (ASL<\/jats:styled-content>) magnetic resonance imaging (MRI<\/jats:styled-content>) can assess cerebral blood flow (CBF<\/jats:styled-content>) without using radiolabeled tracers. It is unknown whether regional increases in CBF<\/jats:styled-content> on ASL MRI<\/jats:styled-content> correlate with seizure location in newborns. We report 3 newborns with focal seizures localized on continuous video electroencephalogram (cEEG<\/jats:styled-content>), anatomical brain MRI, and ASL<\/jats:styled-content> MRI. Each patient underwent pseudocontinuous ASL<\/jats:styled-content> with segmented 3\u2010dimensional fast spin echo readout as part of standard care. Case 1 is a term male infant presenting with left temporal status epilepticus and recurrent cEEG<\/jats:styled-content> seizures from an idiopathic large left intraventricular hemorrhage. ASL<\/jats:styled-content> images demonstrated left mesial temporal lobe increased CBF<\/jats:styled-content>. Case 2 is a late preterm male infant presenting with recurrent cEEG<\/jats:styled-content> seizures due to focal right megalencephaly. Ictal EEG<\/jats:styled-content> and ASL<\/jats:styled-content> images coincided with the focal dysplasia. Case 3 is a dysmorphic term female infant with nonconvulsive partial status epilepticus identified by focal increased CBF<\/jats:styled-content> of the left temporal lobe on ASL<\/jats:styled-content> images. The area of increased CBF<\/jats:styled-content> was within an area of extensive left hemisphere dysplasia. To our knowledge, this is the first report of regional increases in CBF<\/jats:styled-content> on ASL MRI<\/jats:styled-content> correlating with ictal cEEG<\/jats:styled-content> in newborns.<\/jats:p>","DOI":"10.1111\/epi.14060","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T08:16:25Z","timestamp":1522397785000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Increased cerebral blood flow on arterial spin labeling magnetic resonance imaging can localize to seizure focus in newborns: A report of 3 cases"],"prefix":"10.1111","volume":"59","author":[{"given":"Patrick","family":"Mabray","sequence":"first","affiliation":[{"name":"Department of Neurology Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rapeepat","family":"Thewamit","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's National Medical Center Washington DC USA"},{"name":"Department of Pediatrics Faculty of Medicine Prince of Songkla University Songkhla Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew T.","family":"Whitehead","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Kao","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Scafidi","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William D.","family":"Gaillard","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tammy N.","family":"Tsuchida","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's National Medical Center Washington DC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,30]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003072-199309000-00009"},{"key":"e_1_2_5_3_1","first-page":"117","article-title":"Single photon emission computed tomography in intractable infantile seizures","volume":"30","author":"Bye AME","year":"1993","journal-title":"Clin Exp 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