{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:57:49Z","timestamp":1792709869126,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T00:00:00Z","timestamp":1523923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004348","name":"Stockholms L\u00e4ns Landsting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Given the increasing attention being paid to potential strategies for <jats:styled-content style=\"fixed-case\">sudden unexpected death in epilepsy (SUDEP)<\/jats:styled-content> prevention, we analyzed the circumstances of <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> and its incidence in relation to time of year, week, and day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective case\u2010series based on persons with an <jats:styled-content style=\"fixed-case\">International Classification of Diseases (ICD\u201010)<\/jats:styled-content> code for epilepsy in the Swedish Patient Registry 1998\u20102005, who were alive on June 30, 2006 (n = 60 952). Linkage to the National Cause\u2010of\u2010Death Registry identified all deaths from July 2006 through December 2011, with epilepsy mentioned on death certificate, together with all deaths during 2008 (n = 3166). Death certificates, medical charts, autopsy, and police reports were reviewed to identify <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> cases and related circumstances. Autopsied non\u2010<jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> deaths (n = 60) from the study population served as a reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 329 <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>s (63% men) of which 167 were definite, 89 probable, and 73 possible. <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> cases were younger at death (50.8 years) than non\u2010<jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> deaths (73.3 years) (<jats:italic>P<\/jats:italic> &lt; .001) and more likely to be male (63% vs 55%, <jats:italic>P<\/jats:italic> = .0079). Most <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> cases died at night (58%), at home (91%), and 65% were found dead in bed. When documented, 70% were found in prone position. In 17%, death was witnessed and in 88% of these, a seizure was observed. Of the 329 <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> cases, 71% were living alone and 14% shared a bedroom. Compared to an autopsied non\u2010<jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> reference group, definite <jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content>s were more likely to die at home, during the night, unwitnessed, in the prone position, to live alone, and more often with a preceding seizure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">SUDEP<\/jats:styled-content> cases live alone, die unwitnessed at home at night, with indication of a preceding seizure, supporting the critical role of lack of supervision. These facts need to be considered in the development of preventive strategies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.14079","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T08:31:56Z","timestamp":1523953916000},"page":"1074-1082","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Circumstances of SUDEP: A nationwide population\u2010based case series"],"prefix":"10.1111","volume":"59","author":[{"given":"Olafur","family":"Sveinsson","sequence":"first","affiliation":[{"name":"Department of Neurology Karolinska University Hospital Stockholm Sweden"},{"name":"Department of Clinical Neuroscience Karolinska Institute Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Andersson","sequence":"additional","affiliation":[{"name":"Institute of Environmental Medicine Karolinska Institute Stockholm Sweden"},{"name":"Center for Occupational 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