{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:20:55Z","timestamp":1778545255156,"version":"3.51.4"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009237","name":"Svenska F\u00f6reningen f\u00f6r Alkohol- och Drogforskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009237","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Childhood absence epilepsy (<jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content>) is one of the most frequent epilepsies in infancy. The first\u2010line recommended therapy for <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> is based on the prescription of the narrow\u2010spectrum ethosuximide and the broad\u2010spectrum valproic acid, which have similar efficacy in the first 12\u00a0months. Nevertheless, some antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) may worsen seizure duration and type in this syndrome. In line with this, we have encountered a case of identical twins with <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> and early exposure to different antiseizure drugs leading to divergent outcomes. From this, we hypothesized that the first <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> to treat <jats:styled-content style=\"fixed-case\">CAE<\/jats:styled-content> may determine the long\u2010term prognosis, especially in the developing brain, and that some situations leading to drug resistance may be explained by use of an inappropriate first <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>. Therefore, we investigated this hypothesis by using a genetic mouse model of absence epilepsy (<jats:styled-content style=\"fixed-case\">BS<\/jats:styled-content>\/Orl). Mice received a first appropriate or inappropriate <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> followed by the same appropriate <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>. Our data demonstrate that an inappropriate first <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content> has a negative impact on the long\u2010term efficacy of a second appropriate <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>. This work supports the necessity to effectively diagnose epileptic syndromes prior to medication use, particularly in children, in order to prevent the deleterious effects of an inappropriate initial <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/epi.14454","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T11:21:30Z","timestamp":1528975290000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Long\u2010term negative impact of an inappropriate first antiepileptic medication on the efficacy of a second antiepileptic medication in mice"],"prefix":"10.1111","volume":"59","author":[{"given":"Jodi L.","family":"Pawluski","sequence":"first","affiliation":[{"name":"Univ Rennes Inserm EHESP Irset (Research Institute for Environmental and Occupational Health) UMR_S 1085 Rennes 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