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For this narrative review, data were collected using specified search criteria. Articles reporting the evidence for perampanel's efficacy from preclinical models, phase 3 clinical studies, observational studies, and descriptive evidence were included. <jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content> receptors play a key role in mediating the action of glutamate at the excitatory synapse. Preclinical research showed the <jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content> receptor blockade to constitute a promising target for antiepileptic drug therapy. In animal models, perampanel proved to be protective against seizures and reduce seizure severity and duration. Four phase\u20103 randomized controlled trials (3 in patients with focal seizures and one in primary generalized tonic\u2013clonic seizures in idiopathic generalized epilepsy) have been completed. In focal (partial) onset seizures, perampanel (4, 8, and 12\u00a0mg) significantly reduced seizure frequency per 28\u00a0days (23.3%\u201028.8% vs 12.8%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01) and responder rates (\u226550% reduction in seizures) (28.5%\u201035.3% vs 19.3%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05) compared with placebo. In primary generalized tonic\u2013clonic seizures, perampanel 8\u00a0mg resulted in greater reduction in seizure frequency per 28\u00a0days (\u221276.5% vs \u221238.4%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) and responder rate (64.2% vs 39.5%; <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0019) than placebo. The efficacy, safety, and tolerability of perampanel have been reproduced in real\u2010world clinical practice, and the agent has been shown to be effective in other epilepsy syndromes. Perampanel is a potentially broad\u2010spectrum antiepileptic drug with a novel mechanism of action that may be a useful addition for patients with epilepsy with various seizure types. The availability of novel antiepileptic drugs for epilepsy treatment enables more individualized treatment for these patients.<\/jats:p>","DOI":"10.1111\/epi.14456","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T20:31:42Z","timestamp":1530217902000},"page":"22-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Perampanel: Does it have broad\u2010spectrum potential?"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1506-0252","authenticated-orcid":false,"given":"Heidrun","family":"Potschka","sequence":"first","affiliation":[{"name":"Institute of Pharmacology, Toxicology and Pharmacy Ludwig\u2010Maximilians\u2010University (LMU) Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-2692","authenticated-orcid":false,"given":"Eugen","family":"Trinka","sequence":"additional","affiliation":[{"name":"Department of Neurology, Christian Doppler Klinik University Hospital Paracelsus Medical University Salzburg Austria"},{"name":"Institute of Public Health, Medical Decision Making and Health Technology Assessment University for Health Sciences, Medical Informatics and Technology, UMIT Hall in Tyrol Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization. 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