{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:27:32Z","timestamp":1790263652468,"version":"4.1.0"},"reference-count":50,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,6,25]],"date-time":"2018-06-25T00:00:00Z","timestamp":1529884800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The objective of this study was to evaluate effectiveness, retention, and tolerability of brivaracetam (<jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content>) in genetic generalized epilepsies (<jats:styled-content style=\"fixed-case\">GGE<\/jats:styled-content>) in clinical practice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multicenter, retrospective cohort study recruiting all patients that started <jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content> in 2016 and 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 61 patients (mean age = 29.8, range = 9\u201090\u00a0years, 41 female [67%]) were treated with <jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content>. They were difficult to control, with 2.4 failed antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) in the past, taking 1.9 <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s on average at baseline. The length of exposure to <jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content> ranged from 7\u00a0days to 24\u00a0months, with a mean retention time of 7.9\u00a0months, resulting in a total exposure time to <jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content> of 483\u00a0months. The retention rate was 82% at 3\u00a0months and 69% at 6\u00a0months. Efficacy at 3\u00a0months was 36% (50% responder rate), with 25% seizure\u2010free for 3\u00a0months. Patients with juvenile myoclonic epilepsy showed a responder rate of 60%, with 40% being free of any seizures. Long\u2010term 50% responder rate was present in 17 patients (28%; 11 seizure\u2010free [18%]) for &gt;6\u00a0months and in 14 patients (23%; 10 seizure\u2010free [16%]) for &gt;12\u00a0months. Treatment\u2010emergent adverse events were observed in 26% of the patients, with the most common being somnolence, ataxia, and psychobehavioral adverse events. Use of intravenous <jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content> with bolus injection of 200\u2010300\u00a0mg in two females with absence status epilepticus was well tolerated, but did not result in cessation of status epilepticus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Use of <jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content> in <jats:styled-content style=\"fixed-case\">GGE<\/jats:styled-content> is well tolerated, and 50% responder rates are similar to those observed in the regulatory trials for focal epilepsies. An immediate switch from levetiracetam (<jats:styled-content style=\"fixed-case\">LEV<\/jats:styled-content>) to <jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content> at a ratio of 15:1 is feasible. The occurrence of psychobehavioral adverse events seems less prominent than under <jats:styled-content style=\"fixed-case\">LEV<\/jats:styled-content>, and a switch to <jats:styled-content style=\"fixed-case\">BRV<\/jats:styled-content> can be considered in patients with <jats:styled-content style=\"fixed-case\">LEV<\/jats:styled-content>\u2010induced adverse events.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.14476","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T04:50:44Z","timestamp":1529988644000},"page":"1549-1556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Use of brivaracetam in genetic generalized epilepsies and for acute, intravenous treatment of absence status epilepticus"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6288-9915","authenticated-orcid":false,"given":"Adam","family":"Strzelczyk","sequence":"first","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main Department of Neurology Goethe University Frankfurt am Main Germany"},{"name":"Epilepsy Center Hessen and Department of Neurology Philipps University Marburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Kay","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main Department of Neurology Goethe University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Bauer","sequence":"additional","affiliation":[{"name":"Epilepsy Center Frankfurt Rhine\u2010Main Department of Neurology Goethe University Frankfurt am Main 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Charit\u00e9\u2010Universit\u00e4tsmedizin Berlin Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhina","family":"Kunz","sequence":"additional","affiliation":[{"name":"Epilepsy Center Greifswald and Department of Neurology Ernst Moritz Arndt University Greifswald Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Kurlemann","sequence":"additional","affiliation":[{"name":"Department of Neuropediatrics Westf\u00e4lische Wilhelms University M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Langenbruch","sequence":"additional","affiliation":[{"name":"Epilepsy Center M\u00fcnster\u2010Osnabr\u00fcck Department of Neurology Westf\u00e4lische Wilhelms University M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"M\u00f6ddel","sequence":"additional","affiliation":[{"name":"Epilepsy Center 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