{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T02:29:00Z","timestamp":1780626540180,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["25\u20102014\u20100040"],"award-info":[{"award-number":["25\u20102014\u20100040"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004332","name":"Seoul National University Hospital","doi-asserted-by":"publisher","award":["04\u20102016\u20100430"],"award-info":[{"award-number":["04\u20102016\u20100430"]}],"id":[{"id":"10.13039\/501100004332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Anti\u2013leucine\u2010rich glioma\u2010inactivated protein 1 (<jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>1) encephalitis is a rare autoimmune condition presenting mainly as altered mental state, cognitive dysfunction, and seizure. Antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) are usually initiated to control seizures despite their limited efficacy; however, accumulating clinical experience suggests a high incidence of adverse reactions to <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s in anti\u2010<jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>1 encephalitis. We reviewed the medical records of patients who were diagnosed with anti\u2010<jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>1 encephalitis to analyze the adverse effects of <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s in these patients. Among the 20 patients who were treated with <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s, 10 (50%) changed their <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s due to adverse cutaneous drug reaction. Eight of them presented with maculopapular eruption, one with drug rash with eosinophilia and systemic symptoms syndrome, and one with eczema. Causative agents mostly consisted of aromatic <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s. Oxcarbazepine was discontinued in two additional patients due to hyponatremia. Six patients (30%) discontinued their dose of levetiracetam because of psychiatric manifestations including irritability\/aggressive behavior (four patients), insomnia (one patient), and depressive mood (one patient). Clinicians should consider adverse cutaneous drug reaction, psychiatric adverse events, and hyponatremia when selecting <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s for the treatment of anti\u2010<jats:styled-content style=\"fixed-case\">LGI<\/jats:styled-content>1 encephalitis.<\/jats:p>","DOI":"10.1111\/epi.14490","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T10:45:55Z","timestamp":1535625955000},"page":"108-112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Increased adverse events associated with antiepileptic drugs in anti\u2013leucine\u2010rich glioma\u2010inactivated protein 1 encephalitis"],"prefix":"10.1111","volume":"59","author":[{"given":"Yong\u2010Won","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Neurology Comprehensive Epilepsy Center Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital College of Medicine Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon\u2010Jae","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Neurology Comprehensive Epilepsy Center Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital College of Medicine Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jangsup","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Neurology Comprehensive Epilepsy Center Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital College of Medicine Seoul National University Seoul South Korea"},{"name":"Department of Neurosurgery Seoul National University Hospital Seoul South 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Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Ick","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Neurology Kyung Hee University Hospital at Gangdong Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon\u2010Tae","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Comprehensive Epilepsy Center Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital College of Medicine Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keun\u2010Hwa","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Neurology Comprehensive Epilepsy Center Laboratory for Neurotherapeutics Biomedical Research Institute Seoul National University Hospital College of Medicine Seoul National University Seoul South 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