{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:26:54Z","timestamp":1783121214506,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:00:00Z","timestamp":1535328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Epilepsy Research Foundation in Finland"},{"name":"Maire Taponen Foundation"},{"name":"HUCH Neurological Department Research Grant"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Systemic complications are common in status epilepticus. We have no tools to evaluate <jats:italic>total<\/jats:italic> burden of complications and its effect on the outcome of status epilepticus. For Complication Burden Index (CBI) a patient is assessed for 13 complication categories: respiratory, cardiovascular, nervous, renal, hepatic, coagulation, gastrointestinal and musculoskeletal systems, electrolyte\/acid\u2010base balance, infection, hypo\u2010\/hyperglycemia, skin\/allergic reactions, and mental condition. Maximum CBI is 13. CBI was internally validated in a retrospective cohort of 70 consecutive adult patients with generalized convulsive status epilepticus (GCSE) treated in a tertiary hospital over a period of 2\u00a0years. Functional outcome at discharge was defined Poor for Glascow Outcome Scale (GOS) 1\u20103 or worse\u2010than\u2010baseline condition and Good for GOS\u00a0&gt;3 or return to baseline condition. Relative risks (RRs) and receiver\u2010operating characteristic (ROC) \u2010curves were calculated to obtain optimal cutoff. Functional outcome was poor in 40% and worse\u2010than\u2010baseline in 59%. In\u2010hospital mortality was 7%. Average CBI was 3.8 (range 0\u201010, median 3). Cutoff value predicting poor functional outcome was a CBI\u00a0&gt;3 (GOS 1\u20103 RR 1.84, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.045, 95% confidence interval [CI 1.01\u20103.33; ROC\u2010AUC [area under the curve] 0.687, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.008, sensitivity 64%, specificity 61%; worse\u2010than\u2010baseline condition RR 1.52, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.04, 95% CI 1.02\u20102.26; ROC\u2010AUC 0.662, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.022, sensitivity 56%, specificity 69%). CBI with cutoff &gt;3 and as a continuous variable was associated with GOS1\u20103 (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.046, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002) and with worse\u2010than\u2010baseline condition (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.041, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.004). CBI is a novel tool for comprehensive assessment of status epilepticus complications predicting poor\/worse\u2010than\u2010baseline functional outcome with cutoff &gt;3.<\/jats:p>","DOI":"10.1111\/epi.14491","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T00:50:00Z","timestamp":1535590200000},"page":"176-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Complication Burden Index\u2014A tool for comprehensive evaluation of the effect of complications on functional outcome after status epilepticus"],"prefix":"10.1111","volume":"59","author":[{"given":"Leena","family":"K\u00e4mppi","sequence":"first","affiliation":[{"name":"Clinical Neurosciences, Neurology Department of Neurology University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaakko","family":"Ritvanen","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, Neurology Department of Neurology University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Strbian","sequence":"additional","affiliation":[{"name":"Clinical Neurosciences, Neurology Department of Neurology University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harri","family":"Mustonen","sequence":"additional","affiliation":[{"name":"Department of Surgery University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Soinila","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurosciences\/General 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