{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:57:26Z","timestamp":1792299446140,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"S2","license":[{"start":{"date-parts":[[2018,8,29]],"date-time":"2018-08-29T00:00:00Z","timestamp":1535500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01AG026390"],"award-info":[{"award-number":["5R01AG026390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005453","name":"Association of Schools of Public Health","doi-asserted-by":"publisher","award":["S\u20103822"],"award-info":[{"award-number":["S\u20103822"]}],"id":[{"id":"10.13039\/100005453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Children and the elderly (\u226560 years of age) have the highest incidence of<jats:styled-content style=\"fixed-case\">status epilepticus (SE)<\/jats:styled-content>. Because of their general health, elderly individuals are much more likely than younger (&lt;60 years of age) persons to have more severe consequences from seizures. The incidence of<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>is 15.5\/100\u00a0000 in the 60\u201069 age group, 21.5\/100\u00a0000 in the 70\u201079 age group and 25.9\/100\u00a0000 in persons 80 and older. The most common cause in the elderly is acute symptomatic, with stroke and hypoxia the most frequent. The overall mortality of<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>is quite high and occurs early, often within the first few days, and is related to the cause, with mortality of more than 80% in persons with anoxia. Although the cause of<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>is an important factor in mortality, the aging body and brain may contribute to an unfavorable outcome. Treatment in the elderly is essentially the same as in younger adults with benzodiazepines (lorazepam, diazepam, clonazepam) and longer acting antiseizure drugs (phenytoin, fosphenytoin, valproate, levetiracetam, and lacosamide. At this time there are no evidence\u2010based studies regarding Axis 2 (etiology) and Axis 4 (age). All current interventions for<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>involve antiseizure drugs that were developed for treatment of chronic epilepsy. Treatments should be developed that are more specific for the various etiologies and involve drugs that work on the underlying cause of the<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/epi.14497","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T11:28:48Z","timestamp":1535628528000},"page":"140-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Status epilepticus in the elderly"],"prefix":"10.1111","volume":"59","author":[{"given":"Ilo E.","family":"Leppik","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Neurology University of Minnesota Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7551\/mitpress\/6456.003.0004","volume-title":"Status epilepticus: mechnisms and management","author":"DeLorenzo R","year":"2006"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61517-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1684\/j.1950-6945.2005.tb00130.x","article-title":"Nonconvulsive status epilepticus: epilepsy research foundation workshop reports","volume":"7","author":"Walker M","year":"2005","journal-title":"Epileptic Disord"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2014.0709"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1684\/epd.2007.0059","article-title":"Absence status in the elderly as a late complication of idiopathic generalized epilepsies","volume":"9","author":"Bauer G","year":"2007","journal-title":"Epileptic Disord"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2009.02.005"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm5050053"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb06223.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2015.04.065"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2009.02.035"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199809173391202"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2016.11.001"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.28.9.874"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05821.x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12289"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12994"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.14497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.14497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T19:37:27Z","timestamp":1720553847000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.14497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,29]]},"references-count":17,"journal-issue":{"issue":"S2","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["10.1111\/epi.14497"],"URL":"https:\/\/doi.org\/10.1111\/epi.14497","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,29]]},"assertion":[{"value":"2018-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}