{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T16:36:52Z","timestamp":1764002212897},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,7,4]],"date-time":"2018-07-04T00:00:00Z","timestamp":1530662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine whether epilepsy admissions are associated with a higher readmission risk for psychotic episodes compared to admissions for other medical causes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Nationwide Readmissions Database is a nationally representative dataset from 2013. We used <jats:styled-content style=\"fixed-case\">International Classification of Diseases, Ninth Revision, Clinical Modification (ICD<\/jats:styled-content>\u20109\u2010<jats:styled-content style=\"fixed-case\">CM)<\/jats:styled-content> codes to identify medical conditions. There were 58\u00a0278 index admissions for epilepsy, and this group was compared against admissions for stroke (n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>215\u00a0821) and common medical causes (pneumonia, <jats:styled-content style=\"fixed-case\">urinary tract infection [UTI<\/jats:styled-content>], congestive heart failure [<jats:styled-content style=\"fixed-case\">CHF<\/jats:styled-content>], and chronic obstructive pulmonary disease [<jats:styled-content style=\"fixed-case\">COPD<\/jats:styled-content>], n<jats:italic>\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>973\u00a0078). Readmission rates for psychotic episodes within 90\u00a0days from discharge for index hospitalizations were calculated. Cox regression was used to test for associations between admission type and readmission for psychotic episodes up to 1\u00a0year after index admission, in univariate models and adjusted for multiple medical, social, and psychiatric variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Up to 90\u00a0days from index admission, there were 683\/100\u00a0000 readmissions for psychotic episodes in the epilepsy group, 92\/100\u00a0000 in the stroke group, and 58\u2010206\/100\u00a0000 in the medical group. The relative rate of readmission in the epilepsy group was highest in the first 30\u00a0days following index admission (311\/100\u00a0000). Unadjusted hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) for readmission for psychotic episodes within 1\u00a0year in the epilepsy group compared to the stroke group was 6.58 (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI]<\/jats:styled-content> 5.69\u20107.61, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>2\u00a0\u00d7\u00a010<jats:sup>\u221216<\/jats:sup>), and 4.41 compared to the medical group (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 4.00\u20104.85, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>2\u00a0\u00d7\u00a010<jats:sup>\u221216<\/jats:sup>). The fully adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> for readmission in the epilepsy group remained elevated at 3.63 compared to the stroke group (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 3.08\u20104.28, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>2\u00a0\u00d7\u00a010<jats:sup>\u221216<\/jats:sup>), and 1.95 compared to the medical group (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.76\u20102.15, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>2\u00a0\u00d7\u00a010<jats:sup>\u221216<\/jats:sup>). Confounding factors most strongly associated with psychosis readmission were documented psychosis history at the time of index admission, younger age, and lower income quartile.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>An epilepsy admission was independently associated with subsequent hospital readmission for psychotic episodes, even after adjustment for confounding variables.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.14508","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T04:25:20Z","timestamp":1530764720000},"page":"1603-1611","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased risk of hospital admission for <scp>ICD<\/scp>\u20109\u2010<scp>CM<\/scp> psychotic episodes following admission for epilepsy"],"prefix":"10.1111","volume":"59","author":[{"given":"Kyle C.","family":"Rossi","sequence":"first","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna M.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Jett\u00e9","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA"},{"name":"Department of Population Health Science &amp; Policy Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yeoun","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Psychiatry Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mandip S.","family":"Dhamoon","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,4]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.05.043"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-14-75"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.01.011"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-015-0570-4"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-013-0436-x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000284586"},{"key":"e_1_2_7_8_1","first-page":"513","article-title":"Psychoses in epilepsy","volume":"42","author":"Diehl LW","year":"1990","journal-title":"Psychiatr Neurol Med Psychol (Leipz)"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-014-0209-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/15563650.2015.1110590"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291717001118"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02201.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2012.05.009"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.15m10278"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.12125"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21341"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww196"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2017.01.038"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318245f461"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03268.x"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2011.03390.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.38488.462037.8F"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbt043"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2016.16030334"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-004-0715-y"},{"key":"e_1_2_7_26_1","first-page":"3","article-title":"Depression and chronic medical illness","volume":"51","author":"Katon W","year":"1990","journal-title":"J Clin Psychiatry"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/1359105313509845"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fepi.14508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.14508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T16:38:26Z","timestamp":1694968706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.14508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,4]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["10.1111\/epi.14508"],"URL":"https:\/\/doi.org\/10.1111\/epi.14508","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"value":"0013-9580","type":"print"},{"value":"1528-1167","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,4]]},"assertion":[{"value":"2018-06-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-07-04","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}