{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T17:32:35Z","timestamp":1781976755319,"version":"3.54.5"},"reference-count":49,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T00:00:00Z","timestamp":1532995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003769","name":"Eisai","doi-asserted-by":"publisher","award":["VVH\u2010PER\u20102017\u201001"],"award-info":[{"award-number":["VVH\u2010PER\u20102017\u201001"]}],"id":[{"id":"10.13039\/501100003769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyze the effectiveness and tolerability of perampanel across different seizure types in routine clinical care of patients with idiopathic generalized epilepsy (<jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This multicenter, retrospective, 1\u2010year observational study collected data from patient records at 21 specialist epilepsy units in Spain. All patients who were aged \u226512 years, prescribed perampanel before December 2016, and had a confirmed diagnosis of <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content> were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The population comprised 149 patients with <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content> (60 with juvenile myoclonic epilepsy, 51 generalized tonic\u2013clonic seizures [<jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content>] only, 21 juvenile absence epilepsy, 10 childhood absence epilepsy, 6 adulthood absence epilepsy, and one Jeavons syndrome). Mean age was 36 years. The retention rate at 12 months was 83% (124\/149), and 4 mg was the most common dose. At 12 months, the seizure\u2010free rate was 59% for all seizures (88\/149); 63% for <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content> (72\/115), 65% for myoclonic seizures (31\/48), and 51% for absence seizures (24\/47). Seizure frequency was reduced significantly at 12 months relative to baseline for <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content> (78%), myoclonic (65%), and absence seizures (48%). Increase from baseline seizure frequency was seen in 5.2% of patients with <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content> seizures, 6.3% with myoclonic, and 4.3% with absence seizures. Perampanel was effective regardless of epilepsy syndrome, concomitant antiepileptic drugs (<jats:styled-content style=\"fixed-case\">AEDs<\/jats:styled-content>), and prior <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s, but retention and seizure freedom were significantly higher when used as early add\u2010on (after \u22642 prior <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s) than late (\u22653 prior <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s). Adverse events were reported in 50% of patients over 12 months, mostly mild or moderate, and irritability (23%), somnolence (15%), and dizziness (14%) were most frequent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>In routine clinical care of patients with <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>, perampanel improved seizure outcomes for <jats:styled-content style=\"fixed-case\">GTCS<\/jats:styled-content>, myoclonic seizures, and absence seizures, with few discontinuations due to adverse events. This is the first real\u2010world evidence with perampanel across different seizure types in <jats:styled-content style=\"fixed-case\">IGE<\/jats:styled-content>.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.14522","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T07:29:56Z","timestamp":1533022196000},"page":"1740-1752","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":104,"title":["Perampanel in routine clinical use in idiopathic generalized epilepsy: The 12\u2010month GENERAL study"],"prefix":"10.1111","volume":"59","author":[{"given":"Vicente","family":"Villanueva","sequence":"first","affiliation":[{"name":"University Hospital and Polytechnic La Fe Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Montoya","sequence":"additional","affiliation":[{"name":"Lluis Alcanyis Hospital X\u00e1tiva Spain"},{"name":"General University Hospital Valencia 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