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The register is an observational, prospective database, from which this study retrospectively analyzed a cohort. Among the <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>\u2010exposed outcomes, comparisons were made among 3 exposure groups: (1) pregnancy outcomes with first\u2010trimester exposure to <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>s; (2) outcomes with mothers diagnosed with depression and\/or anxiety but who were not medicated with an <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>; and (3) those with mothers who were not diagnosed with depression and\/or anxiety and were not medicating with <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>. Prevalence data was analyzed using Fisher's exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 2124 pregnancy outcomes were included in the analysis; 1954 outcomes were exposed to <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s in utero, whereas 170 were unexposed. Within the group of <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content> taking <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s, there was no significant difference in the prevalence of malformations in infants who were additionally exposed to <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>s (10.2%, 95% <jats:styled-content style=\"fixed-case\">confidence interval [CI]<\/jats:styled-content> 3.9\u201016.6), compared to individuals in the non\u2013<jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>\u2010medicated depression and\/or anxiety group (7.7%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 1.2\u201014.2), or those without depression or anxiety (6.9%, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 5.7\u20108.1; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.45). The malformation rates in pregnancy outcomes unexposed to <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s were also similar in the above groups (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.27). In <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content> medicated with <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>s, the frequency of convulsive seizures (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.78), or nonconvulsive seizures (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.45) throughout pregnancy, did not differ across comparative groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Co\u2010medicating with <jats:styled-content style=\"fixed-case\">ADD<\/jats:styled-content>s in <jats:styled-content style=\"fixed-case\">WWE<\/jats:styled-content> taking <jats:styled-content style=\"fixed-case\">AED<\/jats:styled-content>s does not appear to confer a significant added teratogenic risk, and it does not affect seizure control.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.14539","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T07:24:56Z","timestamp":1535095496000},"page":"1696-1704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The use of antidepressant drugs in pregnant women with epilepsy: A study from the Australian Pregnancy Register"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5106-6806","authenticated-orcid":false,"given":"Niveshan","family":"Sivathamboo","sequence":"first","affiliation":[{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison","family":"Hitchcock","sequence":"additional","affiliation":[{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Graham","sequence":"additional","affiliation":[{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shobi","family":"Sivathamboo","sequence":"additional","affiliation":[{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1888-6917","authenticated-orcid":false,"given":"Zhibin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne Parkville Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence J.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Medicine (The Royal Melbourne Hospital) The University of Melbourne Parkville Victoria Australia"},{"name":"Department of Neurology The Royal Melbourne Hospital Parkville Victoria Australia"},{"name":"Departments of Neuroscience and Neurology Central Clinical School The Alfred Hospital Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank J. 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