{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:52:38Z","timestamp":1790797958499,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T00:00:00Z","timestamp":1539561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000849","name":"National Centre for the Replacement, Refinement and Reduction of Animals in Research","doi-asserted-by":"publisher","award":["G0900775"],"award-info":[{"award-number":["G0900775"]}],"id":[{"id":"10.13039\/501100000849","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Perampanel is an adjunctive treatment for epilepsy that works through the direct inhibition of AMPA receptors. The same molecular mechanism has recently been shown for a fatty acid, decanoic acid, prescribed in the medium chain triglyceride ketogenic diet for the treatment of patients with drug\u2010resistant epilepsy. Because each compound has been proposed to act through a distinct\n                    <jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content>\n                    receptor binding site, we predicted that perampanel and decanoic acid would act synergistically against\n                    <jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content>\n                    receptors and, consequently, seizures. Here, we show a synergistic interaction between perampanel and decanoic acid in direct\n                    <jats:styled-content style=\"fixed-case\">AMPA<\/jats:styled-content>\n                    receptor inhibition, in an ex vivo model of seizure activity, and against seizure\u2010induced activity in human brain slices. These data support a potential role for combination treatment using perampanel and dietary decanoic acid to provide enhanced seizure control.\n                  <\/jats:p>","DOI":"10.1111\/epi.14578","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T01:50:35Z","timestamp":1539654635000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Perampanel and decanoic acid show synergistic action against\n                    <scp>AMPA<\/scp>\n                    receptors and seizures"],"prefix":"10.1111","volume":"59","author":[{"given":"Katrin","family":"Augustin","sequence":"first","affiliation":[{"name":"Centre for Biomedical Sciences School of Biological Sciences Royal Holloway University of London Egham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience University of Newcastle upon Tyne Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita M.","family":"Devlin","sequence":"additional","affiliation":[{"name":"Department of Paediatric Neurology Great North Children's Hospital The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Royal Victoria Infirmary The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashan","family":"Jayasekera","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Royal Victoria Infirmary The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed A.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Royal Victoria Infirmary The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian","family":"Holliman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Royal Victoria Infirmary The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Royal Victoria Infirmary The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alistair","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Royal Victoria Infirmary The Newcastle upon Tyne Hospitals NHS Foundation Trust Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip E.","family":"Chen","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Sciences School of Biological Sciences Royal Holloway University of London Egham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew C.","family":"Walker","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Epilepsy Institute of Neurology University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin S.B.","family":"Williams","sequence":"additional","affiliation":[{"name":"Centre for Biomedical Sciences School of Biological Sciences Royal Holloway University of London Egham 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