{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:32:23Z","timestamp":1785537143302,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KI 835"],"award-info":[{"award-number":["KI 835"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The high incidence of epileptic seizures in neonates and their frequent refractoriness to pharmacologic therapies require identification of new therapeutical options. Therefore, we investigated whether the modulatory effect of taurine on \u03b3\u2010aminobutyric acid (<jats:styled-content style=\"fixed-case\">GABA<\/jats:styled-content>)<jats:sub>A<\/jats:sub>receptors can enhance the anticonvulsive potential of the<jats:styled-content style=\"fixed-case\">GABA<jats:sub>A<\/jats:sub><\/jats:styled-content>receptor agonist muscimol and of the barbiturate pentobarbital.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed field potential recordings in in toto hippocampus preparations of immature (postnatal days 4\u20107) C57Bl\/6 mouse pups. Spontaneous epileptiform activity was induced by the continuous presence of the potassium channel blocker 4\u2010aminopyridine and the glycinergic antagonist strychnine in Mg<jats:sup>2+<\/jats:sup>\u2010free solutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Bath application of 0.1\u00a0\u03bcmol\/L muscimol increases the occurrence of recurrent epileptiform discharges, whereas they are significantly attenuated in a dose\u2010dependent manner by muscimol in concentrations between 0.5 and 5\u00a0\u03bcmol\/L. Taurine at concentrations between 0.1 and 0.5\u00a0mmol\/L induces a proconvulsive effect, but upon coapplication, it significantly augments the anticonvulsive effect of moderate muscimol doses (0.5\u20101\u00a0\u03bcmol\/L). In addition, the anticonvulsive effect of 100 and 200\u00a0\u03bcmol\/L pentobarbital is increased significantly in the presence of 0.5\u00a0\u03bcmol\/L taurine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>These observations demonstrate that taurine can indeed enhance the anticonvulsive effects of muscimol and pentobarbital, suggesting that taurine may act as a positive modulator on<jats:styled-content style=\"fixed-case\">GABA<jats:sub>A<\/jats:sub><\/jats:styled-content>receptors. Thus, interfering with the modulatory taurine binding site of<jats:styled-content style=\"fixed-case\">GABA<jats:sub>A<\/jats:sub><\/jats:styled-content>receptors or the interstitial taurine concentration may provide new therapeutical options for anticonvulsive therapies in neonates.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.14651","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T19:23:15Z","timestamp":1548444195000},"page":"464-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Taurine potentiates the anticonvulsive effect of the<scp>GABA<sub>A<\/sub><\/scp>agonist muscimol and pentobarbital in the immature mouse hippocampus"],"prefix":"10.1111","volume":"60","author":[{"given":"Paula","family":"Winkler","sequence":"first","affiliation":[{"name":"Institute of Physiology University Medical Center of the Johannes Gutenberg University Mainz Mainz 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