{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:26:45Z","timestamp":1792200405321,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006093","name":"Patient-Centered Outcomes Research Institute","doi-asserted-by":"publisher","award":["CER\u20101507\u201031187"],"award-info":[{"award-number":["CER\u20101507\u201031187"]}],"id":[{"id":"10.13039\/100006093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010621","name":"Pediatric Epilepsy Research Foundation","doi-asserted-by":"publisher","award":["A120625"],"award-info":[{"award-number":["A120625"]}],"id":[{"id":"10.13039\/100010621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In a prospective cohort of 534 neonates with acute symptomatic seizures, 66% had incomplete response to the initial loading dose of antiseizure medication (<jats:styled-content style=\"fixed-case\">ASM<\/jats:styled-content>). Treatment response did not differ by gestational age, sex, medication, or dose. The risk of incomplete response was highest for seizures due to intracranial hemorrhage and lowest for hypoxic\u2010ischemic encephalopathy, although the difference was not significant after adjusting for high seizure burden and therapeutic hypothermia treatment. Future trial design may test <jats:styled-content style=\"fixed-case\">ASM<\/jats:styled-content>s in neonates with all acute symptomatic seizure etiologies and could target neonates with seizures refractory to an initial <jats:styled-content style=\"fixed-case\">ASM<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/epi.14671","type":"journal-article","created":{"date-parts":[[2019,2,21]],"date-time":"2019-02-21T06:00:09Z","timestamp":1550728809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Response to antiseizure medications in neonates with acute symptomatic seizures"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3879-1966","authenticated-orcid":false,"given":"Hannah C.","family":"Glass","sequence":"first","affiliation":[{"name":"Departments of Neurology and Pediatrics UCSF Benioff Children's Hospital University of California, San Francisco San Francisco California"},{"name":"Department of Epidemiology &amp; Biostatistics University of California, San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet S.","family":"Soul","sequence":"additional","affiliation":[{"name":"Department of Neurology Boston Children's Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine J.","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Neurology Massachusetts General Hospital Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shavonne L.","family":"Massey","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics Children's Hospital of Philadelphia and Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney J.","family":"Wusthoff","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Neurology Children's National Health System George Washington University School of Medicine Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Roberta","family":"Cilio","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics UCSF Benioff Children's Hospital University of California, San Francisco San Francisco California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia L.","family":"Bonifacio","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine Department of Pediatrics Stanford University Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas S.","family":"Abend","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Pediatrics Children's Hospital of Philadelphia and Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"},{"name":"Departments of Anesthesia and Critical Care Medicine Children's Hospital of Philadelphia Perelman School of Medicine University of Pennsylvania Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Neurology Department of Pediatrics Cincinnati Children's Hospital Medical Center University of Cincinnati Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica","family":"Lemmon","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology and Developmental Medicine Department of Pediatrics Duke University School of Medicine Durham North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles E.","family":"McCulloch","sequence":"additional","affiliation":[{"name":"Department of Epidemiology &amp; 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