{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:41:26Z","timestamp":1767339686821,"version":"3.40.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Epilepsia"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>In patients with status epilepticus (<jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content>) without prior epilepsy, there are limited data on the safety of discontinuing antiseizure drugs (<jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s) after seizure control. We aimed to describe seizure recurrence when weaning from <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s following new onset <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective review of adult patients with <jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content> admitted to Mayo Clinic, Rochester, Minnesota between January 1, 1990 and December 31, 2015 was performed. Weaning was defined as a discontinuation of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s following discharge. Patient demographics, <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> characteristics, timing of <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> withdrawal, and seizure recurrence were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One hundred seventy\u2010seven patients with mean age 63\u00a0\u00b1\u00a018\u00a0years were identified; 96 (54.2%) patients had refractory <jats:styled-content style=\"fixed-case\">SE<\/jats:styled-content> (<jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content>), and 81 (45.8%) had nonrefractory SE. Mean follow\u2010up was 3.8\u00a0\u00b1\u00a03.2\u00a0years for those successfully weaned off <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s. One hundred thirty (73.4%) with outpatient follow\u2010up were included in the analysis; 128 (98.5%) patients were discharged on an <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>; 44 of 128 (34.4%) patients underwent weaning from at least 1 <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> following discharge, including 27 of 128 (21.1%) who were completely weaned off of all <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s. Younger patients (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.009) and those with <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.048, odds ratio = 2.12, 95% confidence interval = 1.00\u20104.48) tended to undergo weaning. Six of 44 (13.6%) patients had seizure recurrence when weaned off of any <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>, and two of 27 (7.4%) patients completely weaned off all <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s had seizure recurrence. Two of seven (28.6%) patients who underwent attempted barbiturate weaning experienced seizure recurrence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>We found a rate of 13.6% for late seizure recurrence after weaning from at least one <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content> in patients with <jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content>; seizure recurrence was more likely in patients with <jats:styled-content style=\"fixed-case\">RSE<\/jats:styled-content> treated with barbiturates. Systematic collection of longitudinal data in patients requiring multiple <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s for <jats:styled-content style=\"fixed-case\">NOSE<\/jats:styled-content> control will provide more conclusive guidance on weaning from <jats:styled-content style=\"fixed-case\">ASD<\/jats:styled-content>s.<\/jats:p><\/jats:sec>","DOI":"10.1111\/epi.14730","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T06:39:40Z","timestamp":1554791980000},"page":"979-985","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Weaning from antiseizure drugs after new onset status epilepticus"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7395-8592","authenticated-orcid":false,"given":"Tia","family":"Chakraborty","sequence":"first","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Hocker","sequence":"additional","affiliation":[{"name":"Department of Neurology Mayo Clinic  Rochester Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2005.01073.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e31829eca06"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.08.006"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001940"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.74.8.1095"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1992.tb01769.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2008.01.002"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2017.12.001"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30114-X"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042098616659414"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc13883"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1989.tb05327.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13121"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.30.8.1538"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70187-9"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.14016"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(87)90002-7"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1684\/epd.2015.0764"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0527-z"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.72.1.22"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418040-00001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0528-y"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2007.01323.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12305"},{"key":"e_1_2_8_26_1","first-page":"1175","volume":"337","year":"1991","journal-title":"Lancet"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1996.tb01023.x"}],"container-title":["Epilepsia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.14730","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/epi.14730","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/epi.14730","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T01:29:44Z","timestamp":1694050184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/epi.14730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/epi.14730"],"URL":"https:\/\/doi.org\/10.1111\/epi.14730","archive":["Portico"],"relation":{},"ISSN":["0013-9580","1528-1167"],"issn-type":[{"type":"print","value":"0013-9580"},{"type":"electronic","value":"1528-1167"}],"subject":[],"published":{"date-parts":[[2019,4,8]]},"assertion":[{"value":"2018-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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